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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19152
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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorTaha, T. E.en
dc.contributor.authorKumwenda, N.en
dc.contributor.authorBroadhead, R.en
dc.contributor.authorMtimavalye, L.en
dc.contributor.authorMiotti, P.en
dc.contributor.authorYellin, F.en
dc.contributor.authorContopoulos-Ioannidis, D. G.en
dc.contributor.authorBiggar, R. J.en
dc.date.accessioned2015-11-24T18:57:18Z-
dc.date.available2015-11-24T18:57:18Z-
dc.identifier.issn0300-5771-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19152-
dc.rightsDefault Licence-
dc.subjectDNA, Viral/analysisen
dc.subject*Disease Transmission, Infectious/prevention & controlen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectGestational Ageen
dc.subjectHIV Antibodies/analysisen
dc.subjectHIV Infections/epidemiology/*transmission/virologyen
dc.subjectHIV-1/genetics/immunologyen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMalawi/epidemiologyen
dc.subjectMaleen
dc.subjectPredictive Value of Testsen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Infectious/epidemiology/virologyen
dc.subjectPrevalenceen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectHIV- infected cohort of delivering women in urban Malawi were studied. The womenen
dc.subjectenrolled in an intervention trial including vaginal cleansing with chlorhexidineen
dc.subjectat the time of delivery. Findings showed that of the 2156 infants born to HIV-en
dc.subjectinfected mothers, about 1359 (63.1%) had been diagnosed with HIV infection, 797en
dc.subject(36.9%) with undetermined status, 144 (6.7%) with missing status, and about 653en
dc.subject(30.3%) were never brought back for follow-up. The odds of HIV positivityen
dc.subjectdecreased in the determination of infectious status (P = 0.03) despite theen
dc.subjectprobability of additional transmission from breast-feeding. Late-coming and losten
dc.subjectchildren of less educated parents had similar birth weight (P = 0.50) and wereen
dc.subjectlikely less to return. This was probably due to the fact that the fathers of theen
dc.subjectlost children were farmers. Besides, infant birth weight, twins vs. singletons,en
dc.subjectand maternal education were affiliated with significant variation in the observeden
dc.subjectrisk of perinatal transmission among HIV-positive infants. Thus, with regard toen
dc.subjectthe intervention trial, the LFU were approximately equal in both groups. Thereen
dc.subjectwas no evidence that the losses were unbalanced between arms in relation to theen
dc.subjectpredictors of transmission.en
dc.titlePredictors and impact of losses to follow-up in an HIV-1 perinatal transmission cohort in Malawien
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10480709-
heal.identifier.secondaryhttp://ije.oxfordjournals.org/content/28/4/769.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1999-
heal.abstractBACKGROUND: Large simple trials which aim to study therapeutic interventions and epidemiological associations of human immunodeficiency virus (HIV) infection, including perinatal transmission, in Africa may have substantial rates of loss to follow-up. A better understanding of the characteristics and the impact of women and children lost to follow-up is needed. METHODS: We studied predictors and the impact of losses to follow-up of infants born in a large cohort of delivering women in urban Malawi. The cohort was established as part of a trial of vaginal cleansing with chlorhexidine during delivery to prevent mother-to-infant transmission of HIV. RESULTS: The HIV infection status could not be determined for 797 (36.9%) of 2156 infants born to HIV-infected mothers; 144 (6.7%) with missing status because of various sample problems and 653 (30.3%) because they never returned to the clinic. Notably, the observed rates of perinatal transmission were significantly lower in infants who returned later for determination of their infection status (odds ratio = 0.94 per month, P = 0.03), even though these infants must have had an additional risk of infection from breastfeeding. In multivariate models, infants of lower birthweight (P = 0.003) and, marginally, singletons (P = 0.09) were less likely to return for follow-up. The parents of infants lost to follow-up tended to be less educated (P < 0.001) and more likely to be in farming occupations, although one educated group, teachers and students, were also significantly less likely to return. Of these variables, infant birthweight, twins versus singletons, and maternal education were also associated with significant variation in the observed risk of perinatal transmission among infants of known HIV status. CONCLUSIONS: Several predictors of loss to follow-up were identified in this large HIV perinatal cohort. Losses to follow-up can impact the observed transmission rate and the risk associations in different studies.en
heal.journalNameInt J Epidemiolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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