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DC Field | Value | Language |
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dc.contributor.author | Bamias, A. | en |
dc.contributor.author | Aravantinos, G. | en |
dc.contributor.author | Kalofonos, C. | en |
dc.contributor.author | Timotheadou, N. | en |
dc.contributor.author | Siafaka, V. | en |
dc.contributor.author | Vlahou, I. | en |
dc.contributor.author | Janinis, D. | en |
dc.contributor.author | Pectasides, D. | en |
dc.contributor.author | Pavlidis, N. | en |
dc.contributor.author | Fountzilas, G. | en |
dc.date.accessioned | 2015-11-24T18:56:43Z | - |
dc.date.available | 2015-11-24T18:56:43Z | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19082 | - |
dc.rights | Default Licence | - |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Anemia, Hypochromic/chemically induced/*prevention & control | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*adverse | en |
dc.subject | effects | en |
dc.subject | Blood Transfusion | en |
dc.subject | Erythropoietin/administration & dosage/*therapeutic use | en |
dc.subject | Female | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasms/*drug therapy | en |
dc.subject | Organoplatinum Compounds/administration & dosage/*adverse effects | en |
dc.subject | Prognosis | en |
dc.subject | Prospective Studies | en |
dc.subject | Quality of Life | en |
dc.subject | Recombinant Proteins | en |
dc.subject | Risk Factors | en |
dc.subject | Treatment Outcome | en |
dc.title | Prevention of anemia in patients with solid tumors receiving platinum-based chemotherapy by recombinant human Erythropoietin (rHuEpo): a prospective, open label, randomized trial by the Hellenic Cooperative Oncology Group | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1159/000067766 | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12566906 | - |
heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000067766&Ausgabe=228855&ProduktNr=223857&filename=000067766.pdf | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2003 | - |
heal.abstract | OBJECTIVES: Platinum compounds are commonly associated with significant anemia. Erythropoietin administration has been found effective in correcting anemia in patients with solid tumors receiving chemotherapy. We conducted a randomized, open label study to assess the efficacy of erythropoietin in preventing transfusions and significant anemia (hemoglobin <10 g/dl) in patients with solid tumors receiving platinum-based chemotherapy. METHODS: One hundred forty-four patients with hemoglobin <13 g/dl were included in this study (72 in each arm). Patients in the treatment arm received 10,000 U of recombinant human erythropoietin (rHuEPO) thrice weekly s.c. during platinum-based chemotherapy, while patients in the control arm received no treatment. RESULTS: All patients were evaluable for efficacy. Transfusions were reduced by the administration of rHuEPO (15.3 vs. 33.3%, p = 0.019), and fewer patients developed significant anemia (16.6 vs. 45.8%, p < 0.0001). Subgroup analysis showed that patients with observed to predicted (O/P) serum erythropoietin levels <or=0.9 and responders to chemotherapy benefited from erythropoietin administration in contrast to patients with O/P >0.9 or non-responders. CONCLUSIONS: rHuEPO at a dose of 10,000 U thrice weekly prevents transfusions and development of significant anemia in patients with solid tumors receiving platinum-based chemotherapy. | en |
heal.journalName | Oncology | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
File | Description | Size | Format | |
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Bamias-2003-Prevention of anemia.pdf | 110.43 kB | Adobe PDF | View/Open Request a copy |
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