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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19071
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dc.contributor.authorBoulland, M. L.en
dc.contributor.authorWechsler, J.en
dc.contributor.authorBagot, M.en
dc.contributor.authorPulford, K.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorGaulard, P.en
dc.date.accessioned2015-11-24T18:56:38Z-
dc.date.available2015-11-24T18:56:38Z-
dc.identifier.issn0309-0167-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19071-
dc.rightsDefault Licence-
dc.subjectAntigens, CD30/*analysisen
dc.subjectAntigens, CD4/analysisen
dc.subjectAntigens, CD8/analysisen
dc.subjectGranzymesen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphoma, T-Cell, Cutaneous/*metabolism/pathologyen
dc.subjectLymphomatoid Papulosis/*metabolism/pathologyen
dc.subjectMembrane Glycoproteins/analysisen
dc.subjectMembrane Proteins/analysisen
dc.subjectPerforinen
dc.subjectPoly(A)-Binding Proteinsen
dc.subjectPore Forming Cytotoxic Proteinsen
dc.subject*Proteinsen
dc.subjectRNA-Binding Proteins/analysisen
dc.subjectReceptors, Antigen, T-Cell, gamma-delta/analysisen
dc.subjectSerine Endopeptidases/analysisen
dc.subjectSkin/chemistry/pathologyen
dc.subjectSkin Neoplasms/*metabolism/pathologyen
dc.subjectT-Lymphocytes, Cytotoxic/metabolismen
dc.titlePrimary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteinsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10672058-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1046/j.1365-2559.2000.00799.x/asset/j.1365-2559.2000.00799.x.pdf?v=1&t=h0eysjfs&s=5a99be6a9609389f48bf14b2901fb095a453d72d-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2000-
heal.abstractAIMS: To analyse the relationship between expression of cytotoxic proteins, histopathology and the CD30 status in primary cutaneous T-cell disorders, we investigated the expression of TIA-1, granzyme B and perforin in CD30 negative and CD30 positive cutaneous T-cell lymphomas (CTCL) and lymphomatoid papulosis (LP). METHODS AND RESULTS: We studied 26 cases of CTCL and 12 cases of LP for the expression of TIA-1, granzyme B and perforin which are granule-associated proteins of cytotoxic lymphocytes involved in the mechanism of apoptosis. We showed that most cases (10/13) of CD30 negative pleomorphic lymphomas expressed cytotoxic proteins only in scattered, apparently reactive lymphocytes, the exception being one CD8+ CTCL and two gammadelta subcutaneous 'panniculitis-like' T-cell lymphomas. We also showed that at least one cytotoxic protein was expressed in a proportion of neoplastic cells in 77% (10/13) of CD30+ T-cell lymphomas (3/4 pleomorphic and 7/9 anaplastic) and in a proportion of atypical cells in 75% (9/12) of LP. CONCLUSIONS: Our findings show a strong correlation between the CD30 phenotype and the expression of cytotoxic proteins in primary CTCL. In addition, these results provide further evidence for an overlap between lymphomatoid papulosis and cutaneous CD30+ pleomorphic and anaplastic lymphomas. These entities, which belong to the spectrum of CD30 positive cutaneous T-cell lymphoproliferations, appear to be derived from cytotoxic cells.en
heal.journalNameHistopathologyen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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