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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19022
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dc.contributor.authorBamias, A.en
dc.contributor.authorBasdanis, G.en
dc.contributor.authorXanthakis, I.en
dc.contributor.authorPavlidis, N.en
dc.contributor.authorFountzilas, G.en
dc.date.accessioned2015-11-24T18:56:20Z-
dc.date.available2015-11-24T18:56:20Z-
dc.identifier.issn1537-3649-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19022-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntineoplastic Agents/administration & dosageen
dc.subjectChemotherapy, Adjuvanten
dc.subjectColorectal Neoplasms/*drug therapy/*radiotherapy/surgeryen
dc.subjectFemaleen
dc.subjectFluorouracil/administration & dosageen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectInterferon-alpha/administration & dosageen
dc.subjectLeucovorin/administration & dosageen
dc.subjectLymphatic Metastasisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectRadiotherapy, Adjuvanten
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectRecombinant Proteinsen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Analysisen
dc.titlePrognostic factors in patients with colorectal cancer receiving adjuvant chemotherapy or chemoradiotherapy: a pooled analysis of two randomized studiesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1385/IJGC:36:1:029-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16227633-
heal.identifier.secondaryhttp://www.springerlink.com/content/q7r0671342113144/fulltext.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2005-
heal.abstractBACKGROUND: Although the TNM system is useful in predicting survival in resected colorectal cancer, heterogeneity within the same stages regarding prognosis exists. We are presenting a pooled analysis of prognostic factors from two randomized studies of adjuvant treatment conducted by the Hellenic Cooperative Oncology Group. PATIENTS AND METHODS: Patients with stage II or III colon (n = 279) or rectal (n = 220) cancer were included in this analysis. Following surgery, patients received: 5-fluorouracil/leucovorin (5-FU/LV) (n = 135), 5-FU/LV and interferon Alfa-2a (IFNA-2a) (n = 138), 5-FU/LV and pelvic chemoradiotherapy (n = 106), and pelvic chemoradiotherapy alone (n = 108). RESULTS: Median follow up was 92 mo. The number of involved lymph nodes (LNs), tumor differentiation, and the presence of regional implants were independent prognostic factors for both OS and TTP, while nerve invasion was only significant for TTP. Patients were stratified into three prognostic groups (low-risk: no LNs and grade 1/2; high-risk: > 3 LNs and grade 3/4; intermediate-risk: remaining patients) with distinct differences in 5-yr survival (84.7% vs 57.6% vs 32.4%) and 5-yr TTP (81.2% vs 54.5% vs 28.6%). CONCLUSION: The combination of clinicopathological prognostic factors can be more informative than the traditional TNM staging system. Such stratification may be necessary in randomized trials and could be useful in deciding the most appropriate adjuvant treatment strategies.en
heal.journalNameInt J Gastrointest Canceren
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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