Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/18948
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Archimandriti, D. T. | en |
dc.contributor.author | Dalavanga, Y. A. | en |
dc.contributor.author | Cianti, R. | en |
dc.contributor.author | Bianchi, L. | en |
dc.contributor.author | Manda-Stachouli, C. | en |
dc.contributor.author | Armini, A. | en |
dc.contributor.author | Koukkou, A. I. | en |
dc.contributor.author | Rottoli, P. | en |
dc.contributor.author | Constantopoulos, S. H. | en |
dc.contributor.author | Bini, L. | en |
dc.date.accessioned | 2015-11-24T18:55:53Z | - |
dc.date.available | 2015-11-24T18:55:53Z | - |
dc.identifier.issn | 1535-3893 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18948 | - |
dc.rights | Default Licence | - |
dc.subject | Asbestos/*adverse effects | en |
dc.subject | Bronchoalveolar Lavage Fluid/*chemistry | en |
dc.subject | Cluster Analysis | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | *Mesothelioma/chemistry/etiology | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Pleural Diseases/*etiology | en |
dc.subject | Proteins/*analysis | en |
dc.subject | Proteome/*analysis | en |
dc.title | Proteome analysis of bronchoalveolar lavage in individuals from Metsovo, nonoccupationally exposed to asbestos | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | 10.1021/pr800370n | - |
heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/19105609 | - |
heal.identifier.secondary | http://pubs.acs.org/doi/abs/10.1021/pr800370n | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
heal.publicationDate | 2009 | - |
heal.abstract | Inhabitants of Metsovo, NW Greece, have been exposed to an asbestos whitewash, resulting in malignant pleural mesothelioma (MPM) and pleural calcifications (PCs). Interestingly, those with PCs (PC(+)) are less prone to MPM. They also have lymphocytic alveolitis, and differences in bronchoalveolar lavage (BAL) proteins, compared with those without pleural calcifications (PC(-)). This may mean a different response to the fiber leading to different susceptibility to neoplasia. To further evaluate this, a proteomic analysis of BAL proteins was performed. Proteomic analysis (2D-electrophoresis/Mass Spectrometry) of BAL in Metsovites nonoccupationally exposed to asbestos revealed increased albumin fragments, alpha1-antitrypsin, S100-A9 and HSP27, suggesting ongoing inflammation. In those without pleural calcifications, increased expression of acid ceramidase, glutathione-S-transferase and presence of calcyphosin, all involved in cell cycle regulation and death as well as in the detoxification of mutagenic and toxic agents, lend further support to our thesis of possible "protection against neoplasia" in Metsovites with pleural calcifications. | en |
heal.journalName | J Proteome Res | en |
heal.journalType | peer-reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ |
Files in This Item:
There are no files associated with this item.
This item is licensed under a Creative Commons License