Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/18814Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pakos, E. E. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T18:55:08Z | - |
| dc.date.available | 2015-11-24T18:55:08Z | - |
| dc.identifier.issn | 0360-3016 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18814 | - |
| dc.rights | Default Licence | - |
| dc.subject | Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use | en |
| dc.subject | *Arthroplasty, Replacement, Hip | en |
| dc.subject | Confidence Intervals | en |
| dc.subject | Dose-Response Relationship, Radiation | en |
| dc.subject | Female | en |
| dc.subject | Hip Fractures/*surgery | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Odds Ratio | en |
| dc.subject | Ossification, Heterotopic/drug therapy/*prevention & control/radiotherapy | en |
| dc.subject | Randomized Controlled Trials as Topic | en |
| dc.title | Radiotherapy vs. nonsteroidal anti-inflammatory drugs for the prevention of heterotopic ossification after major hip procedures: a meta-analysis of randomized trials | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.ijrobp.2003.11.015 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15465207 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0360301603023101/1-s2.0-S0360301603023101-main.pdf?_tid=0d2db4f9a3f7b3ab8113665b80791719&acdnat=1333364403_da0135335ea50f6b0940b6edd536f8da | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | PURPOSE: To evaluate the efficacy of radiotherapy (RT) vs. nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of heterotopic ossification (HO) after major hip procedures. METHODS AND MATERIALS: We conducted a meta-analysis of 7 randomized studies (n = 1143) comparing RT with NSAIDs. Data were combined across studies using fixed and random effects models. We conducted separate analyses for clinically significant HO (Brooker Grade 3 and 4) and for any HO (any Brooker grade). RESULTS: Overall RT tended to be more effective than NSAIDs in preventing Brooker 3 or 4 HO (risk ratio, 0.42; 95% confidence interval [CI], 0.18-0.97) or any HO (risk ratio, 0.75; 95% CI, 0.37-1.71), but with significant between-study heterogeneity for the second analysis. The overall absolute risk difference for Brooker 3 or 4 HO was small (-1.18%; 95% CI, -2.45% to 0.09%). Subgroup analyses showed that early preoperative RT (16-20 hours before surgery) and acetylsalicylic acid were less effective. For postoperative RT, there was a significant dose-response relationship (p = 0.008): 6 Gy of RT was equally effective as NSAIDs, whereas increasing radiation doses were more effective. CONCLUSIONS: Although absolute differences may be small, postoperative RT is on average more effective than NSAIDs in preventing HO after major hip procedures, and its efficacy is dose dependent. | en |
| heal.journalName | Int J Radiat Oncol Biol Phys | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Pakos-2004-Radiotherapy vs. non.pdf | 111.37 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
