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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lakka, S. S. | en |
| dc.contributor.author | Jasti, S. L. | en |
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Yung, W. K. | en |
| dc.contributor.author | Ali-Osman, F. | en |
| dc.contributor.author | Nicolson, G. L. | en |
| dc.contributor.author | Rao, J. S. | en |
| dc.date.accessioned | 2015-11-24T18:54:37Z | - |
| dc.date.available | 2015-11-24T18:54:37Z | - |
| dc.identifier.issn | 0262-0898 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18708 | - |
| dc.rights | Default Licence | - |
| dc.subject | Brain Neoplasms/enzymology/*pathology | en |
| dc.subject | Enzyme Inhibitors/pharmacology | en |
| dc.subject | Flavonoids/pharmacology | en |
| dc.subject | Glioma/enzymology/*pathology | en |
| dc.subject | Humans | en |
| dc.subject | JNK Mitogen-Activated Protein Kinases | en |
| dc.subject | Matrix Metalloproteinase 9/*biosynthesis/genetics | en |
| dc.subject | Mitogen-Activated Protein Kinase 3 | en |
| dc.subject | Mitogen-Activated Protein Kinases/*metabolism | en |
| dc.subject | Promoter Regions, Genetic | en |
| dc.subject | *Signal Transduction | en |
| dc.subject | Transcriptional Activation | en |
| dc.subject | Tumor Cells, Cultured | en |
| dc.title | Regulation of MMP-9 (type IV collagenase) production and invasiveness in gliomas by the extracellular signal-regulated kinase and jun amino-terminal kinase signaling cascades | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11315098 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | Our previous studies have shown that MMP-9 levels are significantly elevated during the progression of human gliomas. In the current study, we examined the role of JNK- and ERK-dependent signaling modules in the regulation of MMP-9 production and the invasive behavior of the human glioblastoma cell line SNB19, in which JNK/ERK1 is constitutively activated. SNB19 cells that were transfected with dominant-negative JNK, MEKK, and ERK1 expression vectors showed reduced MMP-9 promoter activity. In addition, conditioned medium collected from SNB19 cells transfected with these expression vectors showed diminished MMP-9 activity in the presence of phorbol myristate acetate, as determined by gelatin zymography. The cotransfection of SNB19 cells with kinase-deficient c-raf also diminished MMP-9 promoter activity. Further, in the presence of a specific inhibitor of MEKK (PD098059), the Matrigel invasion assay showed the invasiveness of dominant-negative SNB19 cells transfected with dominant-negative JNK1 or ERK1 to be remarkably reduced. In conclusion, our studies showed for the first time that MMP-9 production and the invasive behavior of SNB 19 cells are regulated by JNK- and ERK-dependent signaling modules and that interfering with either of the pathways reduces invasiveness. | en |
| heal.journalName | Clin Exp Metastasis | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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