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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/18699
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dc.contributor.authorLonning, P. E.en
dc.contributor.authorHelle, S. I.en
dc.contributor.authorJohannessen, D. C.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorLien, E. A.en
dc.contributor.authorTally, M.en
dc.contributor.authorEkse, D.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorAnker, G. B.en
dc.contributor.authorHall, K.en
dc.date.accessioned2015-11-24T18:54:33Z-
dc.date.available2015-11-24T18:54:33Z-
dc.identifier.issn0300-0664-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18699-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAndrostenedione/blooden
dc.subjectBreast Neoplasms/*blooden
dc.subjectCarrier Proteins/*metabolismen
dc.subjectEstradiol/blooden
dc.subjectEstrogens/urineen
dc.subjectEstrone/blooden
dc.subjectFemaleen
dc.subjectGonadal Steroid Hormones/*blooden
dc.subjectHumansen
dc.subjectInsulin-Like Growth Factor Binding Protein 1en
dc.subjectInsulin-Like Growth Factor I/*metabolismen
dc.subjectMiddle Ageden
dc.subjectPostmenopause/blooden
dc.subjectSex Hormone-Binding Globulin/*metabolismen
dc.subjectTestosterone/blooden
dc.subjectTime Factorsen
dc.titleRelations between sex hormones, sex hormone binding globulin, insulin-like growth factor-I and insulin-like growth factor binding protein-1 in post-menopausal breast cancer patientsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7534218-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2265.1995.tb02594.x/asset/j.1365-2265.1995.tb02594.x.pdf?v=1&t=h09ak2rc&s=10a9a3eef7e9c70f67410bb6fb72290954660251-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1995-
heal.abstractOBJECTIVE: Oestrogens, androgens and anti-endocrine drugs such as tamoxifen and aminoglutethimide influence plasma insulin-like growth factor-I (IGF-I). IGF-I, in turn, has been found to stimulate the peripheral aromatase in vitro. The aim of this study was to examine relations between sex hormones, IGF-I and insulin-like growth factor binding protein-1 (IGFBP-1) in post-menopausal women with breast cancer. DESIGN: To measure plasma sex steroids, sex hormone binding globulin (SHBG), IGF-I, IGFBP-1, insulin and urinary oestrogen metabolites in post-menopausal women with breast cancer not receiving any endocrine therapy. PATIENTS: Thirty-two patients had fasting blood samples obtained between 0800 and 1000 h. A sub-group of 10 patients had 24-hour urine oestrogen metabolites determined. MEASUREMENTS: Plasma steroids and proteins were measured by radioimmunoassays. Urinary oestrogens were measured by GC-MS. RESULTS: SHBG correlated negatively with plasma androstenedione (P < 0.001), insulin (P < 0.001), IGF-I, height and plasma oestrone sulphate (P < 0.025 for all), but positively with plasma IGFBP-1 (P < 0.025). IGFBP-1 correlated negatively with IGF-I (P < 0.001) and the testosterone/SHBG ratio (P < 0.05). Neither IGF-I nor IGFBP-1 correlated with any of the plasma or urinary sex hormones or with the oestrone/androstenedione and oestradiol/testosterone ratios. Multivariate analysis revealed plasma SHBG to correlate positively with IGFBP-1 (P = 0.029) and negatively with insulin (P = 0.031). Plasma IGFBP-1 correlated negatively with IGF-I (P < 0.0001) but not with insulin. CONCLUSION: Our results do not suggest any influence of plasma sex steroids in physiological concentrations on IGF-I or IGFBP-1 in post-menopausal breast cancer patients, nor do they indicate IGF-I at physiological concentrations influences the ratios between plasma oestrogens and their androgen precursors.en
heal.journalNameClin Endocrinol (Oxf)en
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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