1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/18686
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTzoulaki, I.en
dc.contributor.authorMurray, G. D.en
dc.contributor.authorLee, A. J.en
dc.contributor.authorRumley, A.en
dc.contributor.authorLowe, G. D.en
dc.contributor.authorFowkes, F. G.en
dc.date.accessioned2015-11-24T18:54:28Z-
dc.date.available2015-11-24T18:54:28Z-
dc.identifier.issn1524-4539-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18686-
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAtherosclerosis/epidemiologyen
dc.subjectBiological Markersen
dc.subjectBlood Pressure Determinationen
dc.subjectBlood Proteins/analysisen
dc.subjectBlood Viscosityen
dc.subjectCohort Studiesen
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectFibrinolysisen
dc.subject*Hemorheologyen
dc.subject*Hemostasisen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectInflammation/*epidemiologyen
dc.subjectInflammation Mediators/blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarction/*epidemiology/physiopathologyen
dc.subjectPredictive Value of Testsen
dc.subjectProportional Hazards Modelsen
dc.subjectProspective Studiesen
dc.subjectRisk Factorsen
dc.subjectScotland/epidemiologyen
dc.subjectStroke/*epidemiology/physiopathologyen
dc.titleRelative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1161/CIRCULATIONAHA.106.635029-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17404162-
heal.identifier.secondaryhttp://circ.ahajournals.org/content/115/16/2119.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2007-
heal.abstractBACKGROUND: The aim of our present study was to compare the association of a wide range of 17 biomarkers of inflammation, hemostasis, and blood rheology with incident heart disease and stroke after accounting for an indicator of subclinical atherosclerotic disease and traditional risk factors and also to determine their incremental predictive ability. METHODS AND RESULTS: We used data from the Edinburgh Artery Study, a population cohort study started in 1987 that comprised 1592 men and women aged 55 to 74 years. Subjects were followed for a mean of 17 years, and 416 of them suffered at least 1 cardiovascular event. In analyses adjusted for cardiovascular risk factors and history of cardiovascular disease (CVD): C-reactive protein, interleukin-6, fibrinogen, fibrin D-dimer, tissue plasminogen activator (t-PA), leukocyte elastase, and lipoprotein(a) (all P<0.01), as well as von Willebrand factor and plasma viscosity (both P<0.05), had significant hazard ratios for incident CVD. Further adjustment for a measure of subclinical atherosclerosis (ankle brachial index) had little impact on these associations. The hazard ratios (95% CI) for incident CVD between top and bottom tertiles in the latter analysis were 1.78 (1.30 to 2.45) for C-reactive protein, 1.85 (1.33 to 2.58) for interleukin-6, and 1.76 (1.35 to 2.31) for fibrinogen. Single biomarkers provided little additional discrimination of incident CVD to that obtained from cardiovascular risk factors and the ankle brachial index. An incremental score of multiple markers [interleukin-6, t-PA, intercellular adhesion molecule 1, and lipoprotein(a)] provided some added discrimination. CONCLUSIONS: Several "novel" risk factors predicted CVD after adjustments for conventional risk factors and also for a measure of asymptomatic disease. However, their incremental predictive ability was modest and their clinical utility remains uncertain.en
heal.journalNameCirculationen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

Show simple item record
Files in This Item:
File Description SizeFormat 
Tzoulaki-2007-Relative value of in.pdf300.83 kBAdobe PDFView/Open    Request a copy
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons