Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/18601
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dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorTsokos, M.en
dc.contributor.authorTriche, T. J.en
dc.contributor.authorChader, G. J.en
dc.date.accessioned2015-11-24T18:53:44Z-
dc.date.available2015-11-24T18:53:44Z-
dc.identifier.issn0146-0404-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18601-
dc.rightsDefault Licence-
dc.subjectBucladesine/pharmacologyen
dc.subjectButyric Aciden
dc.subjectButyric Acids/pharmacologyen
dc.subjectCell Differentiation/drug effectsen
dc.subjectCell Lineen
dc.subjectEye Neoplasms/metabolism/*pathology/ultrastructureen
dc.subjectHumansen
dc.subjectMicroscopy, Electronen
dc.subjectRetinoblastoma/metabolism/*pathology/ultrastructureen
dc.subjectStaining and Labelingen
dc.titleRetinoblastoma: a primitive tumor with multipotential characteristicsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2432031-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1986-
heal.abstractThe histogenesis of retinoblastoma, the most common intraocular tumor of childhood, has been recently attributed to a primitive retinal cell which is capable of differentiation into both neuronal and glial elements. By manipulating the culture medium constituents and using differentiating agents, such as dibutyryl-cyclic AMP and butyrate, we have now been able to differentiate a population of Y-79 human retinoblastoma cells into cells of pigment epithelial character, as well as into cells of neuronal or glial nature. These studies additionally implicate the outer layer of the optic vesicle in retinoblastoma etiology, and introduce a new system for studying the biologic properties of primitive neural tumors as well as the embryonic development of the retina and central nervous system.en
heal.journalNameInvest Ophthalmol Vis Scien
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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