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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kolettas, E. | en |
| dc.contributor.author | Thomas, C. | en |
| dc.contributor.author | Leneti, E. | en |
| dc.contributor.author | Skoufos, I. | en |
| dc.contributor.author | Mbatsi, C. | en |
| dc.contributor.author | Sisoula, C. | en |
| dc.contributor.author | Manos, G. | en |
| dc.contributor.author | Evangelou, A. | en |
| dc.date.accessioned | 2015-11-24T18:53:05Z | - |
| dc.date.available | 2015-11-24T18:53:05Z | - |
| dc.identifier.issn | 0300-8177 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18492 | - |
| dc.rights | Default Licence | - |
| dc.subject | Antioxidants/pharmacology | en |
| dc.subject | Apoptosis/*drug effects | en |
| dc.subject | Apoptosis Regulatory Proteins/metabolism | en |
| dc.subject | Cell Proliferation/drug effects | en |
| dc.subject | Cinnamates/*pharmacology | en |
| dc.subject | Depsides | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Humans | en |
| dc.subject | Hydrogen Peroxide/*pharmacology | en |
| dc.subject | Jurkat Cells/*drug effects | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-2/*physiology | en |
| dc.title | Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2 | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1007/s11010-005-9064-8 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16534555 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/996237173447l435/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2006 | - |
| heal.abstract | Rosmarinic acid (RosA), frequently found as a secondary metabolite in herbs and medicinal plants, has exhibited antioxidative and anti-inflammatory activities. RosA was shown to inhibit the proliferation and induce apoptosis of Jurkat T cells but the mechanism of action of RosA in apoptosis remains elusive. RosA inhibited the proliferation of Jurkat cells in a dose-dependent manner by suppressing the expression of cyclin D3 and p21(Cip1/Waf1) and up-regulating p27(Kip1). RosA induced apoptosis of Jurkat cells in a dose-dependent manner and failed to protect them from hydrogen peroxide (H2O2)-mediated apoptosis. Induction of apoptosis by RosA correlated with suppression of Bcl-2 but not of Bak or PUMA. Overexpression of Bcl-2 protected Jurkat cells from both H2O2- and RosA-induced apoptosis by altering the ratio of anti- to pro-apoptotic members of the Bcl-2 family. In conclusion, RosA inhibited Jurkat cell proliferation by altering the expression of cyclins and cyclin-dependent kinase inhibitors and induced apoptosis most likely acting through the mitochondrial pathway and possessed no anti-oxidant properties. | en |
| heal.journalName | Mol Cell Biochem | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kolettas-2006-Rosmarinic acid fail.pdf | 385.45 kB | Adobe PDF | View/Open Request a copy |
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