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https://olympias.lib.uoi.gr/jspui/handle/123456789/18412Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kyzas, P. A. | en |
| dc.contributor.author | Loizou, K. T. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.date.accessioned | 2015-11-24T18:52:34Z | - |
| dc.date.available | 2015-11-24T18:52:34Z | - |
| dc.identifier.issn | 1460-2105 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18412 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Carcinoma, Squamous Cell/chemistry/*mortality/pathology | en |
| dc.subject | Confidence Intervals | en |
| dc.subject | Epidemiologic Research Design | en |
| dc.subject | Female | en |
| dc.subject | Head and Neck Neoplasms/chemistry/*mortality/pathology | en |
| dc.subject | Humans | en |
| dc.subject | Lymphatic Metastasis | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Odds Ratio | en |
| dc.subject | Predictive Value of Tests | en |
| dc.subject | Prognosis | en |
| dc.subject | *Publication Bias | en |
| dc.subject | Research Design | en |
| dc.subject | Risk Assessment | en |
| dc.subject | Risk Factors | en |
| dc.subject | Survival Rate | en |
| dc.subject | Tumor Markers, Biological/*analysis | en |
| dc.subject | Tumor Suppressor Protein p53/*analysis | en |
| dc.subject | United States/epidemiology | en |
| dc.title | Selective reporting biases in cancer prognostic factor studies | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1093/jnci/dji184 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16030302 | - |
| heal.identifier.secondary | http://jnci.oxfordjournals.org/content/97/14/1043.full.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | BACKGROUND: Nonreported and selectively reported information and the use of different definitions may introduce biases in the literature of prognostic factors. We probed these biases in a meta-analysis of a prognostic factor for head and neck squamous cell cancer (HNSCC) mortality that has drawn wide attention--the status of the tumor suppressor protein TP53. METHODS: We compared results of meta-analyses that included published data plus unpublished data retrieved from investigators; published data; and only published data indexed with "survival" or "mortality" in MEDLINE/EMBASE, with or without standardized definitions. We also evaluated whether previously published meta-analyses on mortality predictors for various malignancies addressed issues of retrieval and standardized information. All statistical tests were two-sided. RESULTS: For the 18 studies with 1364 patients that included published and indexed data, we obtained a highly statistically significant association between TP53 status and mortality. When we used the definitions preferred by each publication, the association was stronger (risk ratio [RR] = 1.38, 95% confidence interval [CI] = 1.13 to 1.67; P = .001) than when we standardized definitions (RR = 1.27, 95% CI = 1.06 to 1.53; P = .011). The addition of 13 studies with 1028 subjects that included published but not indexed data reduced the observed association (RR = 1.23, 95% CI = 1.03 to 1.47; P = .02). Finally, when we obtained data from investigators (11 studies with 996 patients) and analyzed it with all other data, statistical significance was lost (RR = 1.16, 95% CI = 0.99 to 1.35; P = .06). Among 18 published meta-analyses of 37 cancer prognostic factors, 13 (72%) did not use standardized definitions and 16 (89%) did not retrieve additional information. CONCLUSIONS: Selective reporting may spuriously inflate the importance of postulated prognostic factors for various malignancies. We recommend that meta-analyses thereof should maximize retrieval of information and standardize definitions. | en |
| heal.journalName | J Natl Cancer Inst | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kyzas-2005-Selective reporting.pdf | 309.11 kB | Adobe PDF | View/Open Request a copy |
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