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dc.contributor.authorKonstantinidis, A.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorPanteli, K.en
dc.contributor.authorConstantopoulos, S.en
dc.date.accessioned2015-11-24T18:51:52Z-
dc.date.available2015-11-24T18:51:52Z-
dc.identifier.issn0025-7931-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18320-
dc.rightsDefault Licence-
dc.subjectACTH Syndrome, Ectopic/etiologyen
dc.subjectAntineoplastic Agents/therapeutic useen
dc.subjectCarboplatin/therapeutic useen
dc.subjectCarcinoma, Small Cell/*complications/drug therapyen
dc.subjectEtoposide/therapeutic useen
dc.subjectHumansen
dc.subjectHypokalemia/*etiologyen
dc.subjectLung Neoplasms/*complications/drug therapyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMuscle Weakness/*etiologyen
dc.titleSevere muscle weakness due to hypokalemia as a manifestation of small-cell carcinomaen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10364746-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000029372&Ausgabe=226553&ProduktNr=224278&filename=000029372.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1999-
heal.abstractWe describe the case of a 56-year-old man with severe muscle weakness due to heavy hypokalemia (serum potassium 1.44 mmol/l) associated with inappropriate kaliuria and alkalemia. Subsequent investigation revealed the presence of ectopic ACTH hypersecretion due to a small-cell lung carcinoma. A significant clinical/laboratory improvement was achieved following chemotherapy-induced regression of the primary tumor. The profound hypokalemia was probably the result of cortisol hypersecretion, which in concert with the ACTH-induced decreased 11beta-hydroxysteroid dehydrogenase activity can exhibit an increased mineralocorticoid activity. In addition, other ACTH-dependent mineralocorticoids may play a contributory role in the development of severe hypokalemia.en
heal.journalNameRespirationen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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