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https://olympias.lib.uoi.gr/jspui/handle/123456789/18306Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Tarassi, K. | en |
| dc.contributor.author | Papadopoulos, I. A. | en |
| dc.contributor.author | Voulgari, P. V. | en |
| dc.contributor.author | Boki, K. A. | en |
| dc.contributor.author | Papasteriades, C. A. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.date.accessioned | 2015-11-24T18:51:47Z | - |
| dc.date.available | 2015-11-24T18:51:47Z | - |
| dc.identifier.issn | 0049-0172 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18306 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Arthritis, Rheumatoid/epidemiology/ genetics/physiopathology | en |
| dc.subject | Female | en |
| dc.subject | Genetic Predisposition to Disease | en |
| dc.subject | Greece/epidemiology | en |
| dc.subject | Histocompatibility Antigens Class II/ genetics | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Mediterranean Region/epidemiology | en |
| dc.subject | Middle Aged | en |
| dc.subject | Severity of Illness Index | en |
| dc.title | Shared epitopes and rheumatoid arthritis: disease associations in Greece and meta-analysis of Mediterranean European populations | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://ac.els-cdn.com/S004901720200001X/1-s2.0-S004901720200001X-main.pdf?_tid=5a4b9aa2-c83e-11e2-826b-00000aacb361&acdnat=1369818270_dbdea779d0df52f927ea30c455f99325 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2002 | - |
| heal.abstract | OBJECTIVES: To assess the strength of the associations between HLA shared epitopes (SE) and rheumatoid arthritis (RA) susceptibility, articular disease severity, and extra-articular features in Mediterranean European populations. METHODS: One hundred and seventy-four Greek RA patients and 103 controls were evaluated. Data were then included in a meta-analysis of 9 studies of Mediterranean European populations (959 RA patients and 1,405 controls). RESULTS: In our study population, SE alleles were significantly more common in RA patients than in controls (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.4-4.3). Larsen radiologic score was predicted by SE and disease duration. SE did not increase the risk of any extra-articular manifestation. The meta-analysis showed a pooled OR of 3.7 (95% CI, 2.6-5.2) for susceptibility to RA conferred by SE (OR, 3.4 v 3.9 in Greek v non-Greek populations). CONCLUSIONS: SE determine articular destruction without increasing the risk of extra-articular manifestations. The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups. | en |
| heal.journalName | Semin Arthritis Rheum | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ioannidis-2002-Shared epitopes and.pdf | 79.39 kB | Adobe PDF | View/Open Request a copy |
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