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dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorSiamopoulou, A.en
dc.contributor.authorPetsoukis, C.en
dc.contributor.authorChalla, A.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorSeferiadis, K.en
dc.rightsDefault Licence-
dc.subjectAdrenergic alpha-Agonists/pharmacologyen
dc.subjectArthritis, Juvenile Rheumatoid/*metabolismen
dc.subjectGlucose Tolerance Testen
dc.subjectGrowth Disorders/metabolismen
dc.subjectGrowth Hormone/pharmacology/*secretionen
dc.subjectInsulin-Like Growth Factor Binding Protein 3/blooden
dc.subjectInsulin-Like Growth Factor I/analysis/biosynthesisen
dc.subjectTime Factorsen
dc.titleStudy of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA)en
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractThe stimulated and spontaneous growth hormone (GH) secretion and the response to GH action were assessed in growth-retarded children with juvenile chronic arthritis (JCA), in order to determine the underlying mechanisms of growth retardation in such children. Six children (4 boys and 2 girls aged 10.7-13.8 years) with active JCA of systemic onset were included in the study which involved: (1) anthropometric measurements; (2) assessment of GH responses to insulin-induced hypoglycaemia and clonidine stimulation; (3) assessment of the nocturnal pulsatile GH secretion by measuring GH in blood samples obtained every 20 min from 20.00 to 08.00 h; and (4) the IGF-I generation test. As a control, the latter test was also performed in eight aged-matched children with physiological delay in puberty. Biosynthetic hGH (0.1 IU/kg BW) was administered s. c. for 4 days and blood samples were taken at baseline and the morning after the last GH injection for measurement of IGF-I and IGFBP-3. All six children with JCA were prepubertal and their growth velocity was <3 cm/year. The GH responses to both stimulation tests were normal (peak GH >20 mU/l). Analysis of the pulsatile GH secretion during the night revealed three-to-four GH pulses of normal amplitude (>20 mU/l). IGF-I (26.7+/-4.6 nmol/l, mean+/-SD) and IGFBP-3 (2.1+/-0.2 mg/l) levels were lower in the patients compared with the controls (43.0+/-3.7 nmol/l and 2.8+/-0.2 mg/l, respectively, P<0.01). Following stimulation with exogenous hGH, there was a significant increase in IGF-I and IGFBP-3 levels in the control group (85 and 73%, respectively), but only a small increase in the patients (31 and 14%). It appears that stimulated and spontaneous GH secretion is normal in children with active systemic JCA, but the response to endogenous and exogenous GH with regard to IGF-I and IGFBP-3 production is impaired, indicating a degree of GH insensitivity in such children.en
heal.journalNameGrowth Horm IGF Resen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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