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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsatsoulis, A. | en |
| dc.contributor.author | Siamopoulou, A. | en |
| dc.contributor.author | Petsoukis, C. | en |
| dc.contributor.author | Challa, A. | en |
| dc.contributor.author | Bairaktari, E. | en |
| dc.contributor.author | Seferiadis, K. | en |
| dc.date.accessioned | 2015-11-24T18:50:14Z | - |
| dc.date.available | 2015-11-24T18:50:14Z | - |
| dc.identifier.issn | 1096-6374 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18048 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Adrenergic alpha-Agonists/pharmacology | en |
| dc.subject | Arthritis, Juvenile Rheumatoid/*metabolism | en |
| dc.subject | Child | en |
| dc.subject | Clonidine/pharmacology | en |
| dc.subject | Female | en |
| dc.subject | Glucose Tolerance Test | en |
| dc.subject | Growth Disorders/metabolism | en |
| dc.subject | Growth Hormone/pharmacology/*secretion | en |
| dc.subject | Humans | en |
| dc.subject | Insulin-Like Growth Factor Binding Protein 3/blood | en |
| dc.subject | Insulin-Like Growth Factor I/analysis/biosynthesis | en |
| dc.subject | Male | en |
| dc.subject | Time Factors | en |
| dc.title | Study of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA) | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1054/ghir.1999.0099 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10373347 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S1096637499900990/1-s2.0-S1096637499900990-main.pdf?_tid=acdadf40106465d449383b2693074148&acdnat=1337336443_1f0488282f262dfef02d9c6118d7fd99 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1999 | - |
| heal.abstract | The stimulated and spontaneous growth hormone (GH) secretion and the response to GH action were assessed in growth-retarded children with juvenile chronic arthritis (JCA), in order to determine the underlying mechanisms of growth retardation in such children. Six children (4 boys and 2 girls aged 10.7-13.8 years) with active JCA of systemic onset were included in the study which involved: (1) anthropometric measurements; (2) assessment of GH responses to insulin-induced hypoglycaemia and clonidine stimulation; (3) assessment of the nocturnal pulsatile GH secretion by measuring GH in blood samples obtained every 20 min from 20.00 to 08.00 h; and (4) the IGF-I generation test. As a control, the latter test was also performed in eight aged-matched children with physiological delay in puberty. Biosynthetic hGH (0.1 IU/kg BW) was administered s. c. for 4 days and blood samples were taken at baseline and the morning after the last GH injection for measurement of IGF-I and IGFBP-3. All six children with JCA were prepubertal and their growth velocity was <3 cm/year. The GH responses to both stimulation tests were normal (peak GH >20 mU/l). Analysis of the pulsatile GH secretion during the night revealed three-to-four GH pulses of normal amplitude (>20 mU/l). IGF-I (26.7+/-4.6 nmol/l, mean+/-SD) and IGFBP-3 (2.1+/-0.2 mg/l) levels were lower in the patients compared with the controls (43.0+/-3.7 nmol/l and 2.8+/-0.2 mg/l, respectively, P<0.01). Following stimulation with exogenous hGH, there was a significant increase in IGF-I and IGFBP-3 levels in the control group (85 and 73%, respectively), but only a small increase in the patients (31 and 14%). It appears that stimulated and spontaneous GH secretion is normal in children with active systemic JCA, but the response to endogenous and exogenous GH with regard to IGF-I and IGFBP-3 production is impaired, indicating a degree of GH insensitivity in such children. | en |
| heal.journalName | Growth Horm IGF Res | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tsatsoulis-1999-Study of growth horm.pdf | 106.54 kB | Adobe PDF | View/Open Request a copy |
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