Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/18038
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dc.contributor.authorTsifetaki, N.en
dc.contributor.authorGeorgiadis, A. N.en
dc.contributor.authorAlamanos, Y.en
dc.contributor.authorFanis, S.en
dc.contributor.authorArgyropoulou, M. I.en
dc.contributor.authorDrosos, A. A.en
dc.date.accessioned2015-11-24T18:50:07Z-
dc.date.available2015-11-24T18:50:07Z-
dc.identifier.issn1502-7732-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18038-
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAtherosclerosis/blood/*complications/ultrasonographyen
dc.subjectCarotid Artery, Common/ultrasonographyen
dc.subjectCholesterol/blooden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPatient Selectionen
dc.subjectRegression Analysisen
dc.subjectScleroderma, Systemic/blood/*complications/ultrasonographyen
dc.subjectSeverity of Illness Indexen
dc.subjectTriglycerides/blooden
dc.titleSubclinical atherosclerosis in scleroderma patientsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.3109/03009741003605648-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20476856-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.3109/03009741003605648-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractOBJECTIVE: To investigate subclinical atherosclerosis in patients with systemic sclerosis (SSc). METHODS: Sixty-six patients with SSc who met the American College of Rheumatology criteria for the disease were included. The serum levels of total cholesterol (TC), triglycerides, high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined in all patients. Carotid artery intima-media thickness (IMT) and carotid plaques were measured. Patients with a history of atherosclerosis, hypertension, smokers, or patients suffering from conditions that affect the lipid profile, such as diabetes mellitus, hypothyroidism, liver or kidney diseases, Cushing's syndrome, obesity, and a history of familial dyslipidaemia, were excluded. Patients receiving medication affecting lipid metabolism were also excluded from the study. Fifty-one age- and sex-matched non-smoking volunteers were used as controls. RESULTS: Sixty patients were investigated. Six were excluded. Of these, two were smokers, two had diabetes mellitus, one hypothyroidism, and one had hypertension treated with diuretics. Patients with SSc exhibited mild dyslipidaemia expressed mainly by low serum levels of HDL-C and high TC (p < 0.001 and p < 0.021, respectively) compared to controls. In addition, the atherogenic ratio LDL-C/HDL-C was significantly higher among SSc patients (p < 0.0001). Common carotid artery IMTs were higher in SSc compared to controls (0.77 +/- 0.2 vs. 0.59 +/- 0.14, p < 0.0001). No correlation between IMTs and any SSc features were found. Logistic regression analysis showed an independent association of scleroderma with IMTs and TC. CONCLUSION: The scleroderma patients exhibited an atherogenic lipid profile and subclinical atherosclerosis and have an increased risk for cardiovascular events.en
heal.journalNameScandinavian Journal of Rheumatologyen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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