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DC Field | Value | Language |
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dc.contributor.author | Zikou, A. K. | en |
dc.contributor.author | Alexiou, G. A. | en |
dc.contributor.author | Kosta, P. | en |
dc.contributor.author | Goussia, A. | en |
dc.contributor.author | Astrakas, L. | en |
dc.contributor.author | Tsekeris, P. | en |
dc.contributor.author | Voulgaris, S. | en |
dc.contributor.author | Malamou-Mitsi, V. | en |
dc.contributor.author | Kyritsis, A. P. | en |
dc.contributor.author | Argyropoulou, M. I. | en |
dc.date.accessioned | 2015-11-24T18:30:19Z | - |
dc.date.available | 2015-11-24T18:30:19Z | - |
dc.identifier.issn | 0303-8467 | - |
dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/16356 | - |
dc.rights | Default Licence | - |
dc.subject | glioma | en |
dc.subject | magnetic resonance imaging | en |
dc.subject | diffusion tensor imaging | en |
dc.subject | perfusion imaging | en |
dc.subject | cerebral blood-volume | en |
dc.subject | brain-tumors | en |
dc.subject | labeling index | en |
dc.subject | astrocytic tumors | en |
dc.subject | nervous-system | en |
dc.subject | glioma grade | en |
dc.subject | perfusion | en |
dc.subject | coefficient | en |
dc.subject | prognosis | en |
dc.subject | permeability | en |
dc.title | Diffusion tensor and dynamic susceptibility contrast MRI in glioblastoma | en |
heal.type | journalArticle | - |
heal.type.en | Journal article | en |
heal.type.el | Άρθρο Περιοδικού | el |
heal.identifier.primary | DOI 10.1016/j.clineuro.2011.12.022 | - |
heal.identifier.secondary | <Go to ISI>://000306044900014 | - |
heal.identifier.secondary | http://ac.els-cdn.com/S030384671100429X/1-s2.0-S030384671100429X-main.pdf?_tid=80582848-ada2-11e2-85c7-00000aacb362&acdnat=1366892602_cc63f0c18388014d2258c8d9e5f43e8d | - |
heal.language | en | - |
heal.access | campus | - |
heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
heal.publicationDate | 2012 | - |
heal.abstract | Objective: We prospectively investigated the correlation between diffusion tensor (DTI), dynamic susceptibility contrast (DSC) perfusion MRI metrics and Ki-67 labelling index in glioblastomas. Methods: We studied seventeen patients who were operated on for glioblastoma. DTI and DSC MRI were performed within a week prior to surgical excision. Lesion/normal ratios were calculated for the apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF) and relative mean transit time (rMTT) ratio. In the excised tumour specimens Ki-67 antigen expression was evaluated by the MIB-1 immunostaining method. Results: A significant correlation was observed between Ki-67 index and ADC ratio (r = -0.528, p = 0.029) and FA ratio (r = 0.589, p = 0.012). rCBV and rMTT presented a trend towards significant correlation with Ki-67 index (r = 0.628, p = 0.07 and r = 0.644, p = 0.06 respectively). There was a trend towards better survival for patients with gross total tumour excision and FA values lower than 0.48 (p = 0.1 and p = 0.09 respectively). No significant correlation was found between ADC ratio, rCBV, rCBF, rMTT and overall survival. Conclusion: ADC ratio, FA ratio, rCBV and rMTT tumour/normal tissue ratios may represent indicators of glioma proliferation. FA values may hold promise for predicting survival in patients with glioblastoma. (C) 2011 Elsevier B.V. All rights reserved. | en |
heal.journalName | Clin Neurol Neurosurg | en |
heal.journalType | peer reviewed | - |
heal.fullTextAvailability | TRUE | - |
Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) |
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Zikou-2012-Diffusion tensor and.pdf | 815.88 kB | Adobe PDF | View/Open Request a copy |
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