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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kiriakogianipsaropoulou, P. | en |
| dc.contributor.author | Malamoumitsi, V. | en |
| dc.contributor.author | Martinopoulou, U. | en |
| dc.contributor.author | Legaki, S. | en |
| dc.contributor.author | Tamvakis, N. | en |
| dc.contributor.author | Vrettou, E. | en |
| dc.contributor.author | Fountzilas, G. | en |
| dc.contributor.author | Skarlos, D. | en |
| dc.contributor.author | Kosmidis, P. | en |
| dc.contributor.author | Pavlidis, N. | en |
| dc.date.accessioned | 2015-11-24T18:29:40Z | - |
| dc.date.available | 2015-11-24T18:29:40Z | - |
| dc.identifier.issn | 0169-5002 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/16283 | - |
| dc.rights | Default Licence | - |
| dc.subject | nsclc | en |
| dc.subject | neuroendocrine markers | en |
| dc.subject | nse | en |
| dc.subject | nftp | en |
| dc.subject | leu-7 | en |
| dc.subject | bombesin | en |
| dc.subject | chromogranin-a | en |
| dc.subject | neuron-specific enolase | en |
| dc.subject | l-dopa decarboxylase | en |
| dc.subject | endocrine differentiation | en |
| dc.subject | chromogranin-a | en |
| dc.subject | tumors | en |
| dc.subject | adenocarcinoma | en |
| dc.subject | carcinoma | en |
| dc.subject | expression | en |
| dc.subject | antibodies | en |
| dc.subject | prognosis | en |
| dc.title | The Value of Neuroendocrine Markers in Nonsmall Cell Lung-Cancer - a Comparative Immunohistopathologic Study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | <Go to ISI>://A1994QN21600002 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/0169500294921644/1-s2.0-0169500294921644-main.pdf?_tid=cdf00f93e120b72df9a44f6809646742&acdnat=1334232104_2fab096428f7781907b9ca5365666805 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.publicationDate | 1994 | - |
| heal.abstract | In order to estimate the value of immunohistochemical identification of neuroendocrine (NE) differentiation markers in non-small cell lung carcinomas (NSCLCs), we investigated the expression of five neuroendocrine and neural differentiation-related antigens in 51 NSCLCs. Additionally, 20 epithelial lung tumors with NE differentiation [15 carcinoids and five small cell lung carcinomas (SCLCs)] and 61 epithelial tumors of various other origin (breast, prostate, colon and head-neck carcinomas) were studied. An indirect two-stage immunoperoxidase method was performed in formalin-fixed and paraffin-embedded tissue specimens, by using commercially available monoclonal antibodies. These antibodies are directed against neuron-specific enolase (NSE), chromogranin-A and Leu-7 which are general markers of NE differentiation, bombesin, which is a specific NE secretory product and neurofilament triplet protein (NFTP), an intermediate filament protein of neuronal differentiation. All five markers demonstrated a positive immunoreactivity in NSCLCs, equally distributed to all three histologic subtypes, ranging from 16 to 47% of the cases (NSE 47%, bombesin 21.5%, Leu-7 21.5%, chromogranin-A 18% and NFTP 16%). Most of the carcinoids and SCLCs expressed multiple or all NE markers. The other four epithelial tumors showed a positive immunoreactivity for bombesin, Leu-7 and NFTP, ranging from 11 to 40% of the cases. Chromogranin-A was not expressed in any of these tumors, whereas NSE was demonstrated only in 17% of breast carcinomas. The following remarks can be drawn from this study: (1) some NSCLCs showed immunophenotypic NE differentiation; (2) among all the markers used, NSE was the most sensitive (sensitivity, 100%) and chromogranin-a the most specific (specificity, 100%); and (3) NSE and chromogranin-A appear to be the most valuable and useful indicators of probable neuroendocrine differentiation in lung epithelial tumors. | en |
| heal.journalName | Lung Cancer | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΦΥΣ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kiriakogianipsaropoulou-1994-The Value of Neuroen.pdf | 4.32 MB | Adobe PDF | View/Open Request a copy |
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