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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/16178
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dc.contributor.authorGogou, P. N.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorPakos, E. E.en
dc.contributor.authorApostolikas, N.en
dc.contributor.authorStefanou, D.en
dc.contributor.authorTsekeris, P. G.en
dc.date.accessioned2015-11-24T18:28:45Z-
dc.date.available2015-11-24T18:28:45Z-
dc.identifier.issn1699-048X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/16178-
dc.rightsDefault Licence-
dc.subjectleiomyosarcomasen
dc.subjecte-cadherinen
dc.subjectbeta-cateninen
dc.subjecttopoisomerase ii alphaen
dc.subjectsoft-tissue sarcomasen
dc.subjectsynovial sarcomaen
dc.subjectcell-adhesionen
dc.subjectdifferentiationen
dc.subjectcarcinomaen
dc.subjectproteinsen
dc.subjectlesionsen
dc.subjectmarkeren
dc.subjectcanceren
dc.subjecttumoren
dc.titleExpression of E-cadherin, beta-catenin and topoisomerase II alpha in leiomyosarcomasen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1007/s12094-009-0401-3-
heal.identifier.secondary<Go to ISI>://000269530200011-
heal.identifier.secondaryhttp://link.springer.com/content/pdf/10.1007%2Fs12094-009-0401-3.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.publicationDate2009-
heal.abstractThe expression of E-cadherin, beta-catenin and topoisomerase II has been associated with clinical outcome of several cancers including sarcomas. We aimed to evaluate the expression of these markers in leiomyosarcomas (LMS). Paraffin blocks of 19 primary, nonmetastatic LMS were analysed immunohistochemically for the expression of the above-mentioned markers with a cutoff level for positivity of 20% of cell staining. Expression of E-cadherin was negative in all LMS. Nuclear expression of beta-catenin was also negative in all cases, while positive cytoplasmic beta-catenin expression was observed in approximately half of the patients. The majority of LMS had expression of topoisomerase II alpha, although only in 10 patients was this expression in more than 20% of tumour cells. From the analysed factors, tumour size was statistically significantly correlated with relapse-free survival. Further evidence with larger series is required in order to determine the implication of these markers in LMS.en
heal.journalNameClinical & Translational Oncologyen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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