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https://olympias.lib.uoi.gr/jspui/handle/123456789/12676Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Alemu, Y. | en |
| dc.contributor.author | Girdhar, G. | en |
| dc.contributor.author | Xenos, M. | en |
| dc.contributor.author | Sheriff, J. | en |
| dc.contributor.author | Jesty, J. | en |
| dc.contributor.author | Einav, S. | en |
| dc.contributor.author | Bluestein, D. | en |
| dc.date.accessioned | 2015-11-24T17:22:52Z | - |
| dc.date.available | 2015-11-24T17:22:52Z | - |
| dc.identifier.issn | 1058-2916 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/12676 | - |
| dc.rights | Default Licence | - |
| dc.subject | induced platelet activation | en |
| dc.subject | damage accumulation | en |
| dc.subject | shear-stress | en |
| dc.subject | flow | en |
| dc.subject | bileaflet | en |
| dc.subject | model | en |
| dc.subject | hinge | en |
| dc.subject | prosthesis | en |
| dc.subject | blood | en |
| dc.subject | performance | en |
| dc.title | Design Optimization of a Mechanical Heart Valve for Reducing Valve Thrombogenicity-A Case Study with ATS Valve | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | Doi 10.1097/Mat.0b013e3181e65bf9 | - |
| heal.identifier.secondary | <Go to ISI>://000281559000002 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικών | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | Patients implanted with mechanical heart valves (MHV) or with ventricular assist devices that use MHV require mandatory lifelong anticoagulation for secondary stroke prevention. We recently developed a novel Device Thrombogenicity Emulator (DTE) methodology that interfaces numerical and experimental approaches to optimize the thrombogenic performance of the device and reduce the bleeding risk associated with anticoagulation therapy. Device Thrombogenicity Emulator uses stress-loading waveforms in pertinent platelet flow trajectories that are extracted from highly resolved numerical simulations and emulates these flow conditions in a programmable hemodynamic shearing device (HSD) by which platelet activity is measured. We have previously compared two MHV, ATS and the St. Jude Medical, and demonstrated that owing to its nonrecessed hinge design, the ATS valve offers improved thrombogenic performance. In this study, we further optimize the ATS valve thrombogenic performance, by modifying various design features of the valve, intended to achieve reduced thrombogenicity: 1) optimizing the leaflet-housing gap clearance; 2) increasing the effective maximum opening angle of the valve; and 3) introducing a streamlined channel between the leaflet stops of the valve that increases the effective flow area. We have demonstrated that the DTE optimization methodology can be used as test bed for developing devices with significantly improved thombogenic performance. ASAIO Journal 2010; 56:389-396. | en |
| heal.publisher | Lippincott, Williams & Wilkins | en |
| heal.journalName | ASAIO Journal (American Society of Artificial Internal Organs) | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΜΑΘ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Xenos-2010-Design optimization of.pdf | 2.38 MB | Adobe PDF | View/Open Request a copy |
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