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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kateri, M. | en |
| dc.contributor.author | Makis, A. C. | en |
| dc.contributor.author | Tzoufi, M. | en |
| dc.contributor.author | Bourantas, K. L. | en |
| dc.contributor.author | Papadopoulou, Z. L. | en |
| dc.date.accessioned | 2015-11-24T17:21:52Z | - |
| dc.date.available | 2015-11-24T17:21:52Z | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/12530 | - |
| dc.rights | Default Licence | - |
| dc.title | Valproate-Induced Eosinophilia in Children With Epilepsy: Role of Interleukin-5 | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1177/08830738050200022201 | - |
| heal.identifier.secondary | http://jcn.sagepub.com/content/20/2/150 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικών | el |
| heal.publicationDate | 2005 | - |
| heal.abstract | Interleukin-5 contributes both in eosinophilopoiesis and neural development. Serum interleukin-5 levels were measured with enzyme-linked immunosorbent assay technique in 68 children with epilepsy receiving sodium valproate monotherapy and compared with the levels of 60 healthy controls and 14 children with epilepsy receiving carbamazepine. Eosinophilia was observed in 35.3% of children receiving valproate. Interleukin-5 in valproate users was significantly higher compared with children receiving carbamazepine and controls. Valproate users who exhibited eosinophilia had higher interleukin-5 levels compared with those without eosinophilia. However, the interleukin-5 level was also elevated, although to a lesser degree, in children without eosinophilia. The majority of valproate responders had high interleukin-5 levels. A positive correlation between interleukin-5 levels and the eosinophil count was also noted. We postulate that valproate contributes to the pathogenesis of eosinophilia, probably inducing interleukin-5 production. The finding that serum interleukin-5 was significantly elevated in valproate responders and even in valproate users without eosinophilia suggests that the increase in interleukin-5 might Sodium valproate is a simple branched-chain fatty acid that has anticonvulsant activity and is widely used in the treatment of epilepsy and convulsive disorders in children, such as generalized tonic-clonic seizures, absence seizures, myoclonic epilepsy, and partial seizures.1 The side effects of valproate in children include gastrointestinal disturbances, hyperphagia, weight gain, alopecia, hepatotoxicity, tremor, behavioral changes, and hematologic toxicity. Thrombocytopenia is a known hematopoietic side effect of valproate monotherapy that can lead to dosage modification or discontinuation. On the other hand, eosinophilia is a side effect that has not been well studied. In a cohort of 134 adult patients treated with valproate, eosinophilia was a noticeable side effect (30%).2 Eosinophilia caused by drugs is usually benign but can sometimes be accompanied by tissue damage, as in hypersensitivity pneumonitis and hypereosinophilic syndrome.3 Recently, a case of eosinophilic pleural effusion with peripheral blood eosinophilia, which was associated with valproate administration, was reported.4 The development and function of both eosinophil precursors and mature eosinophils are mainly regulated by interleukin-5. There is increasing evidence that the secondary eosinophilia present in patients with allergic and parasitic diseases is due to the production of interleukin-5 by activated T cells.5,6 The objective of the present study was to investigate the possible role of interleukin-5 in the production of eosinophilia that occurs in children with epilepsy receiving valproate monotherapy. | en |
| heal.publisher | Sage | en |
| heal.journalName | J Child Neurol | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΜΑΘ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kateri-2005-valproate induced eosinophilia.pdf | 157.08 kB | Adobe PDF | View/Open Request a copy |
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