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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/10611
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dc.contributor.authorGaroufis, A.en
dc.contributor.authorLiu, J. G.en
dc.contributor.authorJi, L. N.en
dc.contributor.authorHadjiliadis, N.en
dc.date.accessioned2015-11-24T16:57:44Z-
dc.date.available2015-11-24T16:57:44Z-
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10611-
dc.rightsDefault Licence-
dc.subjectru(ii) enantiomersen
dc.subjectoligonucleotideen
dc.subjecthpipen
dc.subjectnmren
dc.subjectesi-msen
dc.subjectminor-groove bindingen
dc.subjectionization mass-spectrometryen
dc.subjectsequential resonance assignmentsen
dc.subjectDNA-bindingen
dc.subjectruthenium(ii) complexesen
dc.subjecth-1-nmr spectraen
dc.subjectnmr evidenceen
dc.subjectintercalationen
dc.subjectd(gtcgac)(2)en
dc.subjectspectroscopyen
dc.titleEnantioselective binding of Lambda- and Delta-[Ru(bpy)(2)(HPIP)]Cl-2 (HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline) to the hexanucleotide [d(5 '-GTCGAC-3 ')2]en
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondary<Go to ISI>://000181146400014-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0162013402005755/1-s2.0-S0162013402005755-main.pdf?_tid=96c3b76b34a5a303bb1e7123014ace52&acdnat=1333029207_f1e125c74b354a8ce6b73be99c2fa560-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2003-
heal.abstractMultidimensional NMR techniques (1D (HNMR)-H-1, 2D DQF (HH)-H-1-H-1 COSY and 2D (HH)-H-1-H-1 NOESY), electrospray ionization mass spectrometry (ESI-MS) and electronic spectroscopy, were performed to study the interactions of the enantiomers Lambda- and Delta-[Ru(bpy)(2)(HPIP)]Cl-2, (HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthro-line) with the self complementary hexanucleotide duplex d(5'-GTCGAC-3')(2). The results show that the Delta-[Ru(bpy)(2)(HPIP)]Cl-2 binds tightly to the oligonucleotide, by intercalation of the ligand HPIP, between the A5 and C6 base sequence of the same strand, probably through the minor groove. Lambda-enantiomer binds weakly, suggesting groove interactions with the hexanucleotide duplex. ESI-MS spectrometry and UV-vis spectroscopy also confirmed these observations. (C) 2002 Elsevier Science Inc. All rights reserved.en
heal.publisherElsevieren
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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