Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/10529Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Christidis, D. S. | en |
| dc.contributor.author | Liberopoulos, E. N. | en |
| dc.contributor.author | Kakafika, A. I. | en |
| dc.contributor.author | Miltiadous, G. A. | en |
| dc.contributor.author | Liamis, G. L. | en |
| dc.contributor.author | Kakaidi, B. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Cariolou, M. A. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T16:57:03Z | - |
| dc.date.available | 2015-11-24T16:57:03Z | - |
| dc.identifier.issn | 0188-4409 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10529 | - |
| dc.rights | Default Licence | - |
| dc.subject | paraoxonase | en |
| dc.subject | polymorphism | en |
| dc.subject | lipoprotein-associated phospholipase a(2) | en |
| dc.subject | platelet-activating factor acetylhydrolase | en |
| dc.subject | fluvastatin | en |
| dc.subject | lipids | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | coronary-heart-disease | en |
| dc.subject | c-reactive protein | en |
| dc.subject | middle-aged men | en |
| dc.subject | density-lipoprotein | en |
| dc.subject | serum paraoxonase | en |
| dc.subject | factor-acetylhydrolase | en |
| dc.subject | phospholipase a(2) | en |
| dc.subject | plasma-lipoproteins | en |
| dc.subject | cardiovascular-disease | en |
| dc.title | Effect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatin | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.arcmed.2007.01.006 | - |
| heal.identifier.secondary | <Go to ISI>://000245930700007 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0188440907000367/1-s2.0-S0188440907000367-main.pdf?_tid=4349964eba4f4306b5f088bc6b5046ce&acdnat=1333110993_a2c1a859da84b1283703dcaedc9276ef | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2007 | - |
| heal.abstract | Background. Decreased paraoxonase 1 (PON1) and increased total serum lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activities are suggested to be risk factors for vascular disease. Common PON1 genetic polymorphisms (Q192R and L55M) significantly affect PON1 activity and may also influence high-density lipoprotein (HDL)-associated Lp-PLA(2) activity. However, little is known about the possible effect of PON1 common genetic polymorphisms on the response of lipids as well as PON1 and Lp-PLA(2) activities to treatment with statins. Methods. Two hundred two hypercholesterolemic patients were treated with fluvastatin 40 mg/day. Fasting serum lipids, Q192R and L55M PON1 polymorphisms as well as PON1 and Lp-PLA(2) (total serum and HDL-associated) activities were determined before and after 6 months of treatment. Results. Fluvastatin treatment did not affect HDL-cholesterol or apolipoprotein (apo) AI but resulted in significant decreases in total cholesterol, triglycerides, low-density lipoprotein-cholesterol, apo B and apo E, as well as total serum Lp-PLA(2) activity. In contrast, PON1 activity significantly increased. None of these changes was influenced by Q192R or L55M PON1 polymorphisms. Overall, HDL-Lp-PLA(2) did not change but L55M polymorphism significantly influenced its response to fluvastatin. Specifically, LL homozygotes experienced a significant increase, while M carriers (LM or MM) experienced a non-significant decrease in HDL-Lp-PLA(2) activity (p = 0.030 between groups). Conclusions. Q192R and L55M PON1 polymorphisms did not affect the response of lipids, PON1 and total serum Lp-PLA(2) to treatment with a statin. However, L55M PON1 polymorphism significantly modulated the response of HDL-Lp-PLA(2). It should be noted that this is an association study and therefore provides no proof but only indication that PON1 may also exert Lp-PLA(2) activity in HDL. (C) 2007 IMSS. Published by Elsevier Inc. | en |
| heal.journalName | Arch Med Res | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Christidis-2007-Effect of paraoxonas.pdf | 134.33 kB | Adobe PDF | View/Open Request a copy |
This item is licensed under a Creative Commons License
