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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/10339
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dc.contributor.authorLouppis, A. P.en
dc.contributor.authorBadeka, A. V.en
dc.contributor.authorKatikou, P.en
dc.contributor.authorPaleologos, E. K.en
dc.contributor.authorKontominas, M. G.en
dc.date.accessioned2015-11-24T16:55:40Z-
dc.date.available2015-11-24T16:55:40Z-
dc.identifier.issn0041-0101-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10339-
dc.rightsDefault Licence-
dc.subjectdiarrhetic shellfish poisoningen
dc.subjectokadaic aciden
dc.subjectdinophysistoxinsen
dc.subjectesters of okadaic aciden
dc.subjectmusselsen
dc.subjectmouse bioassayen
dc.subjecthplcen
dc.subjectlc-ms/msen
dc.subjectchromatography-mass-spectrometryen
dc.subjectdiarrhetic shellfish toxinsen
dc.subjectperformance liquid-chromatographyen
dc.subjectlipophilic toxinsen
dc.subjectmarine toxinsen
dc.subjectportuguese bivalvesen
dc.subjectpoisoning toxinsen
dc.subjectthermaikos gulfen
dc.subjectfatty-acidsen
dc.subjectdsp toxinsen
dc.titleDetermination of okadaic acid, dinophysistoxin-1 and related esters in Greek mussels using HPLC with fluorometric detection, LC-MS/MS and mouse bioassayen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.toxicon.2009.10.026-
heal.identifier.secondary<Go to ISI>://000275705300006-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0041010109005157/1-s2.0-S0041010109005157-main.pdf?_tid=716dfd9b8dc7d15b76a0c42a9f0bc3cc&acdnat=1333025075_b904f6133e717da2898f307e2ece7ba5-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2010-
heal.abstractAn approach involving both chemical and biological methods was undertaken for the detection and quantification of the marine toxins okadaic acid (OA), dinophysistoxin-1 (DTX-1) and their respective esters in mussels from different sampling sites in Greece during the period 2006-2007. Samples were analyzed by means of a) high performance liquid chromatography with fluorometric detection (HPLC-FLD), using 9-athryldiazomethane (ADAM), as a pre-column derivatization reagent, b) liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and c) the mouse bioassay. Free OA and DTX-1 were determined by both HPLC-FLD and LC-MS/MS, while their respective esters were determined only by LC-MS/MS after alkaline hydrolysis of the samples. The detection limit (L.O.D.) and quantification limit (L.O.Q) of the HPLC-FLD method were 0.015 mu g/g HP and 0.050 mu g/g HP, respectively, for OA. The detection limit (L.O.D.) and quantification limit (L.O.Q.) of the LC-MS/MS method were 0.045 mu g/g HP and 0.135 mu g/g HP, respectively, for OA. Comparison of results between the two analytical methods showed excellent agreement (100%), while both HPLC-FLD and LC-MS/MS methods showed an agreement of 97.1% compared to the mouse bioassay. (C) 2009 Elsevier Ltd. All rights reserved.en
heal.publisherElsevieren
heal.journalNameToxiconen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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