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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Papatheodorou, L. K. | en |
| dc.contributor.author | Malizos, K. N. | en |
| dc.contributor.author | Poultsides, L. A. | en |
| dc.contributor.author | Hantes, M. E. | en |
| dc.contributor.author | Grafanaki, K. | en |
| dc.contributor.author | Giannouli, S. | en |
| dc.contributor.author | Ioannou, M. G. | en |
| dc.contributor.author | Koukoulis, G. K. | en |
| dc.contributor.author | Protopappas, V. C. | en |
| dc.contributor.author | Fotiadis, D. I. | en |
| dc.contributor.author | Stathopoulos, C. | en |
| dc.date.accessioned | 2015-11-24T17:33:33Z | - |
| dc.date.available | 2015-11-24T17:33:33Z | - |
| dc.identifier.issn | 0301-5629 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/13873 | - |
| dc.rights | Default Licence | - |
| dc.subject | low-intensity ultrasound (lius) | en |
| dc.subject | tendon graft-bone interface healing | en |
| dc.subject | tgf-beta 1 | en |
| dc.subject | biglycan | en |
| dc.subject | collagen type i | en |
| dc.subject | anterior cruciate ligament (acl) | en |
| dc.subject | anterior cruciate ligament | en |
| dc.subject | messenger-rna levels | en |
| dc.subject | pulsed ultrasound | en |
| dc.subject | growth-factors | en |
| dc.subject | patellar tendon | en |
| dc.subject | transforming growth-factor-beta-1 | en |
| dc.subject | autogenous patellar | en |
| dc.subject | collagen-synthesis | en |
| dc.subject | human-fibroblasts | en |
| dc.subject | matrix synthesis | en |
| dc.title | Effect of Transosseous Application of Low-Intensity Ultrasound at the Tendon Graft-Bone Interface Healing: Gene Expression and Histological Analysis in Rabbits | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.ultrasmedbio.2008.07.003 | - |
| heal.identifier.secondary | <Go to ISI>://000264977300007 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0301562908003189/1-s2.0-S0301562908003189-main.pdf?_tid=e4d16a4d2c404021c5fe630029f85292&acdnat=1339758645_b7b6e8c23c877b203f70157d2e32e3c8 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικών | el |
| heal.publicationDate | 2009 | - |
| heal.abstract | The present study investigates the effect of transosseous low-intensity pulsed ultrasound (LiUS) on the healing at tendon graft-bone interface, in molecular and histological level. The anterior cruciate ligament (ACL) in both knees of 52 New Zealand White rabbits was excised and replaced with the long digital extensor. A custom-made ultrasound transducer was implanted onto the medial tibial condyle, adjacent to the surface of the bone tunnel at both knees of the rabbits. The LiUS-treated right knees received 200-mu s bursts of 1 MHz sine waves at a pulse repetition rate of 1 kHz and with 30 MW/cm(2) spatial-average temporal-average intensity for 20 min daily (study group), while the left knee received no LiUS (control group). Thirty-six rabbits were used to perform semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis from both study and control groups for transforming growth factor-beta 1 (TGF-beta 1), biglycan and collagen I. RT-PCR products showed statistically significant upregulation of biglycan and collagen I gene expression in the study group, while TGF-beta 1 gene expression exhibited a bimodal profile. Histological examination performed in 16 rabbits from both groups supported the findings of the molecular analysis, indicating a faster healing rate and a more efficient ligamentization process after ultrasound treatment. These findings suggest that transosseous application of LiUS enhances the healing rate of the tendon graft-bone interface, possibly by affecting the expression levels of genes significant for the tendon to bone healing process. (E-mail: malizos@med.uth.gr) (c) 2009 World Federation for Ultrasound in Medicine & Biology. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | Ultrasound in Medicine and Biology | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Papatheodorou-2009-Effect of Transosseo.pdf | 2.07 MB | Adobe PDF | View/Open Request a copy |
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