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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/13684
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dc.contributor.authorFilipovic, N.en
dc.contributor.authorRosic, M.en
dc.contributor.authorTanaskovic, I.en
dc.contributor.authorMilosevic, Z.en
dc.contributor.authorNikolic, D.en
dc.contributor.authorZdravkovic, N.en
dc.contributor.authorPeulic, A.en
dc.contributor.authorKojic, M. R.en
dc.contributor.authorFotiadis, D. I.en
dc.contributor.authorParodi, O.en
dc.date.accessioned2015-11-24T17:32:11Z-
dc.date.available2015-11-24T17:32:11Z-
dc.identifier.issn1089-7771-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/13684-
dc.rightsDefault Licence-
dc.subjectatherosclerosisen
dc.subjectlow-density lipoprotein (ldl)en
dc.subjectplaqueen
dc.subjectwall shear stressen
dc.titleARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in the Arteriesen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDoi 10.1109/Titb.2011.2168418-
heal.identifier.secondary<Go to ISI>://000304158600013-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.publicationDate2012-
heal.abstractAtherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in 3-D is presented. The blood flow is simulated by the 3-D Navier-Stokes equations, together with the continuity equation while low-density lipoprotein (LDL) transport in lumen of the vessel is coupled with Kedem-Katchalsky equations. The inflammatory process was solved using three additional reaction-diffusion partial differential equations. Transport of labeled LDL was fitted with our experiment on the rabbit animal model. Matching with histological data for LDL localization was achieved. Also, 3-D model of the straight artery with initial mild constriction of 30% plaque for formation and development is presented.en
heal.journalNameIeee Transactions on Information Technology in Biomedicineen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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