Biological studies of new organotin(IV) complexes of thioamide ligands (Journal article)

Xanthopoulou, M. N./ Hadjikakou, S. K./ Hadjiliadis, N./ Milaeva, E. R./ Gracheva, J. A./ Tyurin, V. Y./ Kourkoumelis, N./ Christoforidis, K. C./ Metsios, A. K./ Karkabounas, S./ Charalabopoulos, K.


New organotin(IV) complexes with heterocyclic thioamides 2-mercapto-benzothiazole (Hmbzt), 5-chloro-2-mercapto-benzottliazole (Hcmbzt) and 2-mercapto-benzoxazole (Hmbzo) of formulae [(C(6)H(5))(3)Sn(mbzt)] (1), [(C(6)H(5))(3)Sn(cmbzt)] (3) and [(C(6)H(5))(2)Sn(cmbzt)(2)] (4), together with the already known [(C(6)H(5))(3)Sn(mbzo)] (2), [(n-C(4)H(9))(2)Sn(cmbZt)(2)] (5) and [(CH(3))(2)Sn(cmbzt)(2)] (6) were used to study their influence on the peroxidation of oleic acid. The influence of complexes (3)-(6) upon peroxidation of oleic acid showed that the formation of reactive radicals caused the initiation of the chain radical oxidation of the substrate. The influence of complexes (1)-(6) upon the catalytic peroxidation of linoleic acid by the enzyme lipoxygenase (LOX) was also studied and compared to those of cisplatin. Compounds (1)-(6) were finally tested for in vitro cytotoxicity against leiomyosarcoma cells. (c) 2007 Elsevier Masson SAS. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: bioinorganic chemistry,organotin(iv) complexes,s ligands-heterocyclic thioamides,catalytic peroxidation of fatty acids,cytotoxic action,structural-characterization,platinum compounds,linoleic-acid,binding-site,derivatives,5-chloro-2-mercaptobenzothiazole,triethyltin,2-mercaptobenzothiazole,lipoxygenase,peroxidation
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/9981
ISSN: 0223-5234
Link: <Go to ISI>://000254031400011
http://ac.els-cdn.com/S0223523407001614/1-s2.0-S0223523407001614-main.pdf?_tid=d6e4d31afbc398a09721d1bac770dc2d&acdnat=1333030315_ac546532df6fa05fba711ce1cb5a2776
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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