Synthesis, study, and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activity (Journal article)

Zachariadis, P. C./ Hadjikakou, S. K./ Hadjiliadis, N./ Michaelides, A./ Skoulika, S./ Ming, Y./ Xiaolin, Y.

Silver(I) chloride reacts with 2-mercapto-nicotinic acid (H2mna, C6H5NO2S) in the presence of an excess of triethylamine in DMSO to form a hexanuclear, water soluble, cluster of formula {[Ag6(m3-Hmna)4(m3-mna)2]2 /[(Et3NH) ]2 /(DMSO)2 /(H2O)} (1). The complex 1 was characterized by elemental analyses, and FT-IR, UV /Vis and 1H NMR spectroscopy. Crystal structures of complex 1 and the ligand, 2-mecapto-nicotinic acid (2), have been determined by X-ray diffraction. Compound 1, C52H68Ag6- N8O15S8, is monoclinic with a space group P21/c (No. 14) and a /11.7080(10), b /16.2920(10), c /18.3010(10) A Β° , b /91.350(10)8, Z /4. The entire molecule is ionic and consists of a double anionic hexa-nuclear cluster and two protonated triethylamine counter cations while it is solvated by two DMSO and one water molecule. The 2-mercapto-nicotinic acid (2), C6H5NO2S, is orthorhombic (space group Pna21 (No. 33), a /8.3910(10), b /13.2720(10), c /5.892 A Β° , Z /4). An extended inter-molecular hydrogen bonding via O H /N contacts (O(1) H(5)[N(5)] /1.8998, O(1) N(5) /2.8049 A Β° ) links the molecules forming a supramolecular twodimensional network. Complex 1, was evaluated for anti-HIV-RT activity. It was found to inhibit the human immunodeficiency viral replication reverse transcriptase (HIV-RT) with calculated inhibiting concentration (IC50) 0.012759/0.00115 mg ml 1.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: Bioinorganic chemistry,Silver(I) complexes,2-Mercapto-nicotinic acid,Crystal structures,Anti-HIV-RT activity
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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