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dc.contributor.authorZachariadis, P. C.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorHadjiliadis, N.en
dc.contributor.authorMichaelides, A.en
dc.contributor.authorSkoulika, S.en
dc.contributor.authorMing, Y.en
dc.contributor.authorXiaolin, Y.en
dc.date.accessioned2015-11-24T16:49:53Z-
dc.date.available2015-11-24T16:49:53Z-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9540-
dc.rightsDefault Licence-
dc.subjectBioinorganic chemistryen
dc.subjectSilver(I) complexesen
dc.subject2-Mercapto-nicotinic aciden
dc.subjectCrystal structuresen
dc.subjectAnti-HIV-RT activityen
dc.titleSynthesis, study, and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activityen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.sciencedirect.com/science/article/pii/S0020169302012100#-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2003-
heal.abstractSilver(I) chloride reacts with 2-mercapto-nicotinic acid (H2mna, C6H5NO2S) in the presence of an excess of triethylamine in DMSO to form a hexanuclear, water soluble, cluster of formula {[Ag6(m3-Hmna)4(m3-mna)2]2 /[(Et3NH) ]2 /(DMSO)2 /(H2O)} (1). The complex 1 was characterized by elemental analyses, and FT-IR, UV /Vis and 1H NMR spectroscopy. Crystal structures of complex 1 and the ligand, 2-mecapto-nicotinic acid (2), have been determined by X-ray diffraction. Compound 1, C52H68Ag6- N8O15S8, is monoclinic with a space group P21/c (No. 14) and a /11.7080(10), b /16.2920(10), c /18.3010(10) A Β° , b /91.350(10)8, Z /4. The entire molecule is ionic and consists of a double anionic hexa-nuclear cluster and two protonated triethylamine counter cations while it is solvated by two DMSO and one water molecule. The 2-mercapto-nicotinic acid (2), C6H5NO2S, is orthorhombic (space group Pna21 (No. 33), a /8.3910(10), b /13.2720(10), c /5.892 A Β° , Z /4). An extended inter-molecular hydrogen bonding via O H /N contacts (O(1) H(5)[N(5)] /1.8998, O(1) N(5) /2.8049 A Β° ) links the molecules forming a supramolecular twodimensional network. Complex 1, was evaluated for anti-HIV-RT activity. It was found to inhibit the human immunodeficiency viral replication reverse transcriptase (HIV-RT) with calculated inhibiting concentration (IC50) 0.012759/0.00115 mg ml 1.en
heal.publisherElsevieren
heal.journalNameInorganica Chimica Actaen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ

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