Lack of effect of acute repaglinide administration on postprandial lipaemia in patients with type 2 diabetes mellitus (Journal article)

Tentolouris, N./ Kolia, M./ Tselepis, A. D./ Perea, D./ Kitsou, E./ Kyriaki, D./ Tambaki, A. P./ Karabina, S. P./ Sala, C./ Fragoulopoulos, E./ Katsilambros, N.


The effect of acute repaglinide administration (2 mg) on postprandial glycaemia and lipaemia has been examined in 20 subjects with type 2 diabetes mellitus. Each subject received in the morning, after a 12 to 14 h fast, a standard mixed meal (total energy 783 kcal), preceded by one tablet of 2 mg repaglinide or placebo. Chylomicrons and chylomicron-deficient plasma were prepared by ultracentrifugation. Triglyceride levels in CM fraction (CM-triglycerides) in total plasma as well as in CM-deficient plasma (non-CM-triglycerides) were determined. A significant reduction in postprandial glycaemia was observed after repaglinide administration compared to placebo (p < 0.001). Plasma concentrations of total triglycerides, CM-triglycerides, non-CM-triglycerides, free fatty acids and the other plasma lipids measured, were not significantly different between the two phases of the study. It is concluded that, in contrast to sulphonylureas, acute repaglinide administration does not improve postprandial lipaemia in patients with type 2 diabetes.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: repaglinide,type 2 diabetes mellitus,triglycerides,postprandial triglyceridaemia,lipoprotein subfractions,triglyceride,metabolism,niddm
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/8336
ISSN: 0947-7349
Link: <Go to ISI>://000185875000012
https://www.thieme-connect.de/DOI/DOI?10.1055/s-2003-42729
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
There are no files associated with this item.



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/8336
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.