C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors (Journal article)

Ioannidis, P./ Trangas, T./ Dimitriadis, E./ Samiotaki, M./ Kyriazoglou, I./ Tsiapalis, C. M./ Kittas, C./ Agnantis, N./ Nielsen, F. C./ Nielsen, J./ Christiansen, J./ Pandis, N.


Mouse coding region determinant-binding (mCRD-BP) and human IGF-II mRNA-binding 1 (hIMP-1) proteins are orthologous mRNA-binding proteins that recognize c-myc and IGF-II mRNA, respectively, and regulate their expression posttranscriptionally. Here, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were found to express hCRD-BP/IMP-1. In particular, expression was significant in 14 Ewing's sarcomas, all of which were positive. The data suggest that hCRD-BP/IMP-1 plays a role in abnormal cell proliferation in mesenchymal tumors.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: Amino Acid Motifs,Animals,Base Sequence,Cell Division,Chromosome Mapping,DNA, Complementary/metabolism,Humans,Mesenchymoma/*metabolism,Mice,Molecular Sequence Data,Protein Binding,Proto-Oncogene Proteins c-myc/metabolism,RNA/metabolism,RNA,
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/7565
ISSN: 0020-7136
Link: http://www.ncbi.nlm.nih.gov/pubmed/11745432
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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