Tetranectin expression in gastric adenocarcinomas (Journal article)

Arvanitis, D. L./ Kamper, E. F./ Kopeikina, L./ Stavridou, A./ Sgantzos, M. N./ Kallioras, V./ Athanasiou, E./ Kanavaros, P.


AIMS: The aim was to analyze the immunohistochemical localization of tetranectin in gastric adenocarcinomas and the adjacent tissues of the wall of the stomach. METHODS AND RESULTS: Forty cases of gastric adenocarcinomas were stained by the indirect immunoperoxidase method. Of the ten cases of mucinous signet ring cell carcinomas 5 showed high, 3 moderate and 2 low tetranectin expression. Of the ten cases of well-differentiated intestinal type adenocarcinomas (ITA) 4 showed moderate regional, 3 low regional and 3 negative tetranectin expression. Of the ten cases of moderately-differentiated ITA 3 showed moderate regional, 4 low regional and 3 negative tetranectin expression. Of the ten cases of poorly-differentiated ITA 4 showed focal low and 6 negative tetranectin expression. Overall, the mucinous signet ring carcinomas showed significantly higher tetranectin expression compared to ITA (chi2 = 3.95, p<0.05). In contrast, no significant relationship was found between tetranectin expression and the degree of differentiation in ITA (chi2 = 2.5, p>0.05). In all cases, the perineoplastic desmoplastic reactive stroma showed high expression of tetranectin intra- and extracellularly. The mast cells and goblet cells in the areas of intestinal metaplasia showed high tetranectin expression. CONCLUSIONS: This study shows that: a) tetranectin is produced and deposited extracellularly in the desmoplastic peritumoral stroma of infiltrating gastric adenocarcinomas; b) tetranectin is more highly expressed by the mucinous signet ring cell carcinomas compared to ITA; and c) the amount of tetranectin produced by the ITA is unrelated with the degree of tumor differentiation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenocarcinoma/*metabolism/pathology,Adenocarcinoma, Mucinous/*metabolism/pathology,Blood Proteins/*biosynthesis,Carcinoma, Signet Ring Cell/*metabolism/pathology,Humans,*Lectins, C-Type,Stomach/*metabolism/pathology,Stomach Neoplasms/*metabolism/pathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24678
ISSN: 0213-3911
Link: http://www.ncbi.nlm.nih.gov/pubmed/11962752
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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