The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer (Journal article)

Vairaktaris, E./ Yapijakis, C./ Nkenke, E./ Vassiliou, S./ Vylliotis, A./ Nixon, A. M./ Derka, S./ Ragos, V./ Spyridonidou, S./ Tsigris, C./ Neukam, F. W./ Patsouris, E.


No studies thus far have investigated the contribution of thrombin activatable fibrinolysis inhibitor (TAFI) to oral oncogenesis. We studied the activity-related 1040C/T polymorphism in 150 patients with oral cancer and 138 healthy controls matched by age, gender, and ethnicity. The increased-activity T allele frequency was significantly reduced in patients compared with controls (28.7% vs. 37.0%, P < 0.05). T/T homozygotes had about half the probability of developing oral cancer (O.R. 0.39, 95%C.I. 0.13-1.14), while no significant difference was observed in C/T heterozygotes. The observed prophylactic effect of increased TAFI activity might result from reduction of plasmin and inhibition of extracellular matrix dissolution.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Aged, 80 and over,Carboxypeptidase U/*genetics,Carcinoma, Squamous Cell/*genetics,Case-Control Studies,Female,Gene Frequency,*Genetic Predisposition to Disease,Germany,Greece,Homozygote,Humans,Male,Middle Aged,Mouth Neoplasms/*genetics,Polymorphism, Single Nucleotide/*genetics
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/24670
ISSN: 0361-8609
Link: http://www.ncbi.nlm.nih.gov/pubmed/17636471
http://onlinelibrary.wiley.com/store/10.1002/ajh.20985/asset/20985_ftp.pdf?v=1&t=h0atvxln&s=71caa113aec971d022dddc814abf1874ce031163
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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