Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis (Journal article)

Fang, Y./ Rivadeneira, F./ van Meurs, J. B./ Pols, H. A./ Ioannidis, J. P./ Uitterlinden, A. G.

INTRODUCTION: Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting. MATERIALS AND METHODS: We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models. RESULT: No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones. CONCLUSION: No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Aged, 80 and over,Deoxyribonucleases, Type II Site-Specific/metabolism,Female,Fractures, Bone/*genetics,Gene Frequency,Genetic Predisposition to Disease/genetics,Humans,Male,Middle Aged,Odds Ratio,Osteoporosis/genetics,*Polymorphism, Restriction Fragment Length,Receptors, Calcitriol/*genetics
ISSN: 8756-3282
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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