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https://olympias.lib.uoi.gr/jspui/handle/123456789/24483Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Fang, Y. | en |
| dc.contributor.author | Rivadeneira, F. | en |
| dc.contributor.author | van Meurs, J. B. | en |
| dc.contributor.author | Pols, H. A. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Uitterlinden, A. G. | en |
| dc.date.accessioned | 2015-11-24T19:41:27Z | - |
| dc.date.available | 2015-11-24T19:41:27Z | - |
| dc.identifier.issn | 8756-3282 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24483 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Deoxyribonucleases, Type II Site-Specific/metabolism | en |
| dc.subject | Female | en |
| dc.subject | Fractures, Bone/*genetics | en |
| dc.subject | Gene Frequency | en |
| dc.subject | Genetic Predisposition to Disease/genetics | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Odds Ratio | en |
| dc.subject | Osteoporosis/genetics | en |
| dc.subject | *Polymorphism, Restriction Fragment Length | en |
| dc.subject | Receptors, Calcitriol/*genetics | en |
| dc.title | Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1016/j.bone.2006.04.016 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16769262 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S8756328206004145/1-s2.0-S8756328206004145-main.pdf?_tid=6583be43c469e20f85a1fcdc7b8938e6&acdnat=1333364235_16dbb28a1f53d14dc53af56b81add44b | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2006 | - |
| heal.abstract | INTRODUCTION: Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting. MATERIALS AND METHODS: We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models. RESULT: No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones. CONCLUSION: No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data. | en |
| heal.journalName | Bone | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Fang-2006-Vitamin D receptor g.pdf | 320.1 kB | Adobe PDF | View/Open Request a copy |
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