Anticardiolipin antibodies in unselected autoimmune rheumatic disease patients (Journal article)

Manoussakis, M. N./ Gharavi, A. E./ Drosos, A. A./ Kitridou, R. C./ Moutsopoulos, H. M.


Quantitative determination of IgG and IgM antibodies to cardiolipin (anti-CL) was performed with a newly developed sensitive and specific ELISA method. We studied a cohort of 361 unselected patients with various autoimmune rheumatic diseases (ARD), 69 patients with thromboembolic phenomena (TEP) unassociated with ARD, and 267 healthy blood donors (HBD). Anti-CL of at least one immunoglobulin class were found in 42 (11.6%) of the ARD patients, in 3 (4.3%) of the TEP patients (2 with myocardial infarction and 1 with pulmonary emboli), and in 6 (2.3%) of the HBD. In ARD patients anti-CL were more prevalent in patients with systemic lupus erythematosus (SLE) and overlap syndromes. Significant correlations included CNS involvement (particularly seizures) and features of immune hyperreactivity (splenomegaly-lymphadenopathy, ANA, and antibodies to Ro(SSA), U1-nRNP, and double-stranded DNA). No statistical correlation could be demonstrated between the presence of anti-CL and thrombotic events, hematologic disorders, or recurrent abortions in the ARD patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Aged, 80 and over,Autoantibodies/*analysis/immunology,Autoimmune Diseases/*immunology,Cardiolipins/*immunology,Enzyme-Linked Immunosorbent Assay,Female,Humans,Immunoglobulin G/analysis,Immunoglobulin M/analysis,Male,Middle Aged,Rheumatic Diseases/*immunology,Thromboembolism/*immunology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23801
ISSN: 0090-1229
Link: http://www.ncbi.nlm.nih.gov/pubmed/3497746
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Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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