B-cell differentiation immunophenotypes in classical Hodgkin lymphomas (Journal article)

Bai, M./ Panoulas, V./ Papoudou-Bai, A./ Horianopoulos, N./ Kitsoulis, P./ Stefanaki, K./ Rontogianni, D./ Agnantis, N. J./ Kanavaros, P.

The bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis of the immunohistochemical positivity of Hodgkin and Reed-Sternberg (H/RS) cells: (a) the late germinal center (GC)/early post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138-); 59/101 cases (59%), (b) the post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138+); 24/101 cases (24%) and (c) the indeterminate immunophenotype (bcl6+/CD10-/MUM1+/CD138-: 14 cases and bcl6+/CD10-/MUM1+/CD138+: four cases); 18/101 cases (18%). The above findings indicate that H/RS cells in most cHL display bcl6/CD10/MUM1/CD138 immunophenotypes consistent with late GC/early post-GC or post-GC B-cell differentiation. In addition, H/RS cells in a small fraction of cHL display indeterminate bcl6/CD10/MUM1/CD138 immunophenotypic profiles which are characterized by simultaneous expression of GC, late GC/early post-GC and post-GC B-cell differentiation proteins. These immunophenotypic profiles do not correspond to the differentiation immunophenotypes of normal B-cells and their identification in a part of cHL suggests that the differentiation process of H/RS cells is not complete in a fraction of these cells and/or is still ongoing at the time of observation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antigens, Differentiation/biosynthesis,B-Lymphocytes/*immunology/pathology,Cell Differentiation/*immunology,Germinal Center/pathology,Hodgkin Disease/*immunology/pathology,Humans,Immunohistochemistry,Immunophenotyping,Interferon Regulatory Factors/biosynthesis,Membrane Glycoproteins/biosynthesis,Neprilysin/biosynthesis,Phenotype,Proteoglycans/biosynthesis,Proto-Oncogene Proteins c-bcl-6/biosynthesis,Syndecan-1,Syndecans
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/23535
ISSN: 1042-8194
Link: http://www.ncbi.nlm.nih.gov/pubmed/16396774
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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