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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bai, M. | en |
| dc.contributor.author | Panoulas, V. | en |
| dc.contributor.author | Papoudou-Bai, A. | en |
| dc.contributor.author | Horianopoulos, N. | en |
| dc.contributor.author | Kitsoulis, P. | en |
| dc.contributor.author | Stefanaki, K. | en |
| dc.contributor.author | Rontogianni, D. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.contributor.author | Kanavaros, P. | en |
| dc.date.accessioned | 2015-11-24T19:33:25Z | - |
| dc.date.available | 2015-11-24T19:33:25Z | - |
| dc.identifier.issn | 1042-8194 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23535 | - |
| dc.rights | Default Licence | - |
| dc.subject | Antigens, Differentiation/biosynthesis | en |
| dc.subject | B-Lymphocytes/*immunology/pathology | en |
| dc.subject | Cell Differentiation/*immunology | en |
| dc.subject | Germinal Center/pathology | en |
| dc.subject | Hodgkin Disease/*immunology/pathology | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Immunophenotyping | en |
| dc.subject | Interferon Regulatory Factors/biosynthesis | en |
| dc.subject | Membrane Glycoproteins/biosynthesis | en |
| dc.subject | Neprilysin/biosynthesis | en |
| dc.subject | Phenotype | en |
| dc.subject | Proteoglycans/biosynthesis | en |
| dc.subject | Proto-Oncogene Proteins c-bcl-6/biosynthesis | en |
| dc.subject | Syndecan-1 | en |
| dc.subject | Syndecans | en |
| dc.title | B-cell differentiation immunophenotypes in classical Hodgkin lymphomas | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1080/10428190500306784 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16396774 | - |
| heal.identifier.secondary | http://informahealthcare.com/doi/abs/10.1080/10428190500306784 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2006 | - |
| heal.abstract | The bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis of the immunohistochemical positivity of Hodgkin and Reed-Sternberg (H/RS) cells: (a) the late germinal center (GC)/early post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138-); 59/101 cases (59%), (b) the post-GC B-cell-like immunophenotype (bcl6-/CD10-/MUM1+/CD138+); 24/101 cases (24%) and (c) the indeterminate immunophenotype (bcl6+/CD10-/MUM1+/CD138-: 14 cases and bcl6+/CD10-/MUM1+/CD138+: four cases); 18/101 cases (18%). The above findings indicate that H/RS cells in most cHL display bcl6/CD10/MUM1/CD138 immunophenotypes consistent with late GC/early post-GC or post-GC B-cell differentiation. In addition, H/RS cells in a small fraction of cHL display indeterminate bcl6/CD10/MUM1/CD138 immunophenotypic profiles which are characterized by simultaneous expression of GC, late GC/early post-GC and post-GC B-cell differentiation proteins. These immunophenotypic profiles do not correspond to the differentiation immunophenotypes of normal B-cells and their identification in a part of cHL suggests that the differentiation process of H/RS cells is not complete in a fraction of these cells and/or is still ongoing at the time of observation. | en |
| heal.journalName | Leuk Lymphoma | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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