Communication: synthesis of a novel triphenyltin(IV) derivative of 2- mercaptonicotinic acid with potent cytotoxicity in vitro (Journal article)

Xanthopoulou, M. N./ Hadjikakou, S. K./ Hadjiliadis, N./ Schurmann, M./ Jurkschat, K./ Binolis, J./ Karkabounas, S./ Charalabopoulos, K.


A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (H(2)mna) of formula {[(C(6)H(5))(3)Sn](2)(mna).[(CH(3))(2)CO]} (1) has been synthesized and characterized by elemental analysis and (1)H, (13)C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (H(>2)mna). It is an example of a pentacoordinated Ph(3)SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22941
ISSN: 1565-3633
Link: http://www.ncbi.nlm.nih.gov/pubmed/18365056
http://downloads.hindawi.com/journals/bca/2003/346578.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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