Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPELT uptake (Journal article)

Alexiou, G. A./ Tsiouris, S./ Vartholomatos, G./ Fotakopoulos, G./ Papadopoulos, A./ Kyritsis, A. P./ Voulgaris, S./ Fotopoulos, A. D.

Objectives: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. Material and methods: In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision. Results: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between 99mTc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (C) 2009 Elsevier B.V. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: glioma,flow cytometry,(99m)tc-tetrofosmin spect,cell nuclear antigen,brain-tumors,DNA-content,tl-201,spect,tc-99m-sestamibi,glioblastoma,tc-99m-mibi,tetrofosmin,grade
ISSN: 0303-8467
Link: <Go to ISI>://000272256800004
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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