Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPELT uptake (Journal article)

Alexiou, G. A./ Tsiouris, S./ Vartholomatos, G./ Fotakopoulos, G./ Papadopoulos, A./ Kyritsis, A. P./ Voulgaris, S./ Fotopoulos, A. D.


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dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorTsiouris, S.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorFotakopoulos, G.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorFotopoulos, A. D.en
dc.date.accessioned2015-11-24T19:26:48Z-
dc.date.available2015-11-24T19:26:48Z-
dc.identifier.issn0303-8467-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/22759-
dc.rightsDefault Licence-
dc.subjectgliomaen
dc.subjectflow cytometryen
dc.subject(99m)tc-tetrofosmin specten
dc.subjectcell nuclear antigenen
dc.subjectbrain-tumorsen
dc.subjectDNA-contenten
dc.subjecttl-201en
dc.subjectspecten
dc.subjecttc-99m-sestamibien
dc.subjectglioblastomaen
dc.subjecttc-99m-mibien
dc.subjecttetrofosminen
dc.subjectgradeen
dc.titleCorrelation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPELT uptakeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.clineuro.2009.08.009-
heal.identifier.secondary<Go to ISI>://000272256800004-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0303846709002121/1-s2.0-S0303846709002121-main.pdf?_tid=683945acd493ec61f3a08db08a30de29&acdnat=1332758521_2645f3349f9f6f9401be6ba1a83f103f-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2009-
heal.abstractObjectives: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. Material and methods: In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision. Results: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between 99mTc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (C) 2009 Elsevier B.V. All rights reserved.en
heal.journalNameClin Neurol Neurosurgen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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