Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI (Journal article)
Tzarouchi, L. C./ Xydis, V./ Zikou, A. K./ Drougia, A./ Astrakas, L. G./ Papastefanaki, M./ Andronikou, S./ Argyropoulou, M. I.
BACKGROUND: Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL). OBJECTIVE: Evaluate changes in the volume of 116 GM areas in preterm children with dPVL. METHODS AND MATERIALS: Eleven preterm children with dPVL, gestational age 32.8 +/- 2.6 weeks, examined at corrected age 22.0 +/- 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation. RESULTS: Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P < 0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P < 0.05) and lower WM volume/higher CSF volume (P < 0.05). WM/CSF ratios also differed (P < 0.05). CONCLUSIONS: Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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