Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI (Journal article)

Tzarouchi, L. C./ Xydis, V./ Zikou, A. K./ Drougia, A./ Astrakas, L. G./ Papastefanaki, M./ Andronikou, S./ Argyropoulou, M. I.

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dc.contributor.authorTzarouchi, L. C.en
dc.contributor.authorXydis, V.en
dc.contributor.authorZikou, A. K.en
dc.contributor.authorDrougia, A.en
dc.contributor.authorAstrakas, L. G.en
dc.contributor.authorPapastefanaki, M.en
dc.contributor.authorAndronikou, S.en
dc.contributor.authorArgyropoulou, M. I.en
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dc.titleDiffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRIen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractBACKGROUND: Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL). OBJECTIVE: Evaluate changes in the volume of 116 GM areas in preterm children with dPVL. METHODS AND MATERIALS: Eleven preterm children with dPVL, gestational age 32.8 +/- 2.6 weeks, examined at corrected age 22.0 +/- 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation. RESULTS: Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P < 0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P < 0.05) and lower WM volume/higher CSF volume (P < 0.05). WM/CSF ratios also differed (P < 0.05). CONCLUSIONS: Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory.en
heal.journalNamePediatric Radiologyen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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