Effect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndrome (Journal article)

Dalavanga, Y. A./ Detrick, B./ Hooks, J. J./ Drosos, A. A./ Moutsopoulos, H. M.

Labial minor salivary gland biopsy specimens from 14 patients with Sjogren's syndrome treated either with cyclosporin A (CyA) or placebo (5 mg/kg body weight day for six months) were studied to determine T lymphocyte subsets and HLA-DR antigen expression using the avidin-biotin-peroxidase technique. In all CyA treated patients we observed a decrease in the number of T lymphocytes and in the number of T helper cells, while the percentage of T suppressor cells and B cells was the same in both treated and untreated groups. It was also shown that the HLA-DR antigen expression on the epithelial cells was eliminated in the CyA treated patients. These findings suggest that the HLA-DR antigen expression on the epithelial cells is the result rather than the triggering factor of this T cell mediated process and is probably related to decreased lymphokine production by activated T lymphocytes.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Cyclosporins/*therapeutic use,Female,HLA-DR Antigens/analysis,Humans,Male,Salivary Glands/*drug effects,Salivary Glands, Minor/*drug effects/immunology/pathology,Sjogren's Syndrome/*drug therapy/immunology/pathology,T-Lymphocytes/pathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/22225
ISSN: 0003-4967
Link: http://www.ncbi.nlm.nih.gov/pubmed/3493738
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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