Effect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndrome (Journal article)

Dalavanga, Y. A./ Detrick, B./ Hooks, J. J./ Drosos, A. A./ Moutsopoulos, H. M.


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dc.contributor.authorDalavanga, Y. A.en
dc.contributor.authorDetrick, B.en
dc.contributor.authorHooks, J. J.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:23:00Z-
dc.date.available2015-11-24T19:23:00Z-
dc.identifier.issn0003-4967-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/22225-
dc.rightsDefault Licence-
dc.subjectCyclosporins/*therapeutic useen
dc.subjectFemaleen
dc.subjectHLA-DR Antigens/analysisen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectSalivary Glands/*drug effectsen
dc.subjectSalivary Glands, Minor/*drug effects/immunology/pathologyen
dc.subjectSjogren's Syndrome/*drug therapy/immunology/pathologyen
dc.subjectT-Lymphocytes/pathologyen
dc.titleEffect of cyclosporin A (CyA) on the immunopathological lesion of the labial minor salivary glands from patients with Sjogren's syndromeen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3493738-
heal.identifier.secondaryhttp://ard.bmj.com/content/46/2/89.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1987-
heal.abstractLabial minor salivary gland biopsy specimens from 14 patients with Sjogren's syndrome treated either with cyclosporin A (CyA) or placebo (5 mg/kg body weight day for six months) were studied to determine T lymphocyte subsets and HLA-DR antigen expression using the avidin-biotin-peroxidase technique. In all CyA treated patients we observed a decrease in the number of T lymphocytes and in the number of T helper cells, while the percentage of T suppressor cells and B cells was the same in both treated and untreated groups. It was also shown that the HLA-DR antigen expression on the epithelial cells was eliminated in the CyA treated patients. These findings suggest that the HLA-DR antigen expression on the epithelial cells is the result rather than the triggering factor of this T cell mediated process and is probably related to decreased lymphokine production by activated T lymphocytes.en
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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