Evaluation of the association of autoantibodies with mortality in the very elderly: a cohort study (Journal article)

Ioannidis, J. P./ Katsifis, G. E./ Stavropoulos, E. D./ Manoussakis, M. N./ Moutsopoulos, H. M.


OBJECTIVE: To evaluate whether autoantibodies in the absence of rheumatic diseases increase the risk of mortality among very elderly subjects who are otherwise in good functional condition. METHODS: Autoantibodies were measured in 1987 in 156 elderly nursing home residents (median age 84 yr) who were followed subsequently over 14.6 yr. RESULTS: Eleven subjects had anticardiolipin antibodies, 30 had rheumatoid factor and 19 had antibodies to single-stranded DNA (ssDNA). Other autoantibodies were more rare. During follow-up, 144 subjects died. Adjusting for age as a time-dependent covariate, the hazard ratio for death was 0.71 [95% confidence interval (CI) 0.38-1.32] for anticardiolipin antibodies, 0.93 (95% CI 0.60-1.41) for rheumatoid factor, 1.08 (95% CI 0.65-1.79) for antibodies to ssDNA, and 0.99 (95% CI, 0.70-1.41) for any autoantibody. Hazard ratios were similar when adjusted also for sex and clinical conditions. CONCLUSION: Our results exclude the possibility that the autoantibodies evaluated increase substantially the risk of death among very elderly subjects in good functional condition.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Aged, 80 and over,Aging/*immunology,Antibodies, Anticardiolipin/blood,Antibodies, Antinuclear/blood,Autoantibodies/*blood,Cohort Studies,DNA, Single-Stranded/immunology,Female,Follow-Up Studies,Humans,Male,Proportional Hazards Models,Rheumatoid Factor/blood,Risk Factors,Survival Analysis,Survival Rate
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/21800
ISSN: 1462-0324
Link: http://www.ncbi.nlm.nih.gov/pubmed/12595636
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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