Transforming growth factor-beta inhibition attenuates pulmonary arterial hypertension in rats (Journal article)

Megalou, A. J./ Glava, C./ Oikonomidis, D. L./ Vilaeti, A./ Agelaki, M. G./ Baltogiannis, G. G./ Papalois, A./ Vlahos, A. P./ Kolettis, T. M.


The role of transforming growth factor-beta in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-beta receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced pulmonary hypertension. One week after monocrotaline injection (60 mg/kg) in 28 Wistar rats, T9429 (0.1mg/kg daily) was administered intraperito-neally in 19 rats (268+/-10g) via an osmotic mini-pump for 7 days. One week thereafter, right ventricular systolic pressure, pulmonary vascular remodeling and exercise tolerance were evaluated. Compared to the monocrotaline group (25.5+/-1.9mmHg), right ventricular systolic pressure was lower (p=0.0014) in the monocrotaline+antibody group (18.4+/-0.8mmHg). This was translated into attenuated right ventricular hypertrophy (p=0.0063) and longer (p=0.0155) exercise duration (2.08+/-0.29min versus 6.19+/-1.02min). Pulmonary arterial wall thickness (in vessels 50 -200mum) was comparable between the two groups, but the monocrotaline+antibody group displayed lower number (p<0.0001) of pre-capillary arterioles (<50mum, in 20 randomly selected fields) with a muscularized media (23.33+/-3.15 versus 6.64+/-0.75). Our results suggest that transforming growth factor-beta receptor blockade improves vascular remodeling and attenuates pulmonary hypertension, a finding with potential therapeutic implications.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/20920
ISSN: 1940-5901
Link: http://www.ncbi.nlm.nih.gov/pubmed/21072267
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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