Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/20920
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dc.contributor.authorMegalou, A. J.en
dc.contributor.authorGlava, C.en
dc.contributor.authorOikonomidis, D. L.en
dc.contributor.authorVilaeti, A.en
dc.contributor.authorAgelaki, M. G.en
dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorVlahos, A. P.en
dc.contributor.authorKolettis, T. M.en
dc.date.accessioned2015-11-24T19:11:20Z-
dc.date.available2015-11-24T19:11:20Z-
dc.identifier.issn1940-5901-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20920-
dc.rightsDefault Licence-
dc.titleTransforming growth factor-beta inhibition attenuates pulmonary arterial hypertension in ratsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21072267-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractThe role of transforming growth factor-beta in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-beta receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced pulmonary hypertension. One week after monocrotaline injection (60 mg/kg) in 28 Wistar rats, T9429 (0.1mg/kg daily) was administered intraperito-neally in 19 rats (268+/-10g) via an osmotic mini-pump for 7 days. One week thereafter, right ventricular systolic pressure, pulmonary vascular remodeling and exercise tolerance were evaluated. Compared to the monocrotaline group (25.5+/-1.9mmHg), right ventricular systolic pressure was lower (p=0.0014) in the monocrotaline+antibody group (18.4+/-0.8mmHg). This was translated into attenuated right ventricular hypertrophy (p=0.0063) and longer (p=0.0155) exercise duration (2.08+/-0.29min versus 6.19+/-1.02min). Pulmonary arterial wall thickness (in vessels 50 -200mum) was comparable between the two groups, but the monocrotaline+antibody group displayed lower number (p<0.0001) of pre-capillary arterioles (<50mum, in 20 randomly selected fields) with a muscularized media (23.33+/-3.15 versus 6.64+/-0.75). Our results suggest that transforming growth factor-beta receptor blockade improves vascular remodeling and attenuates pulmonary hypertension, a finding with potential therapeutic implications.en
heal.journalNameInt J Clin Exp Meden
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ

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