Influence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective study (Journal article)

Drosos, A. A./ Tsifetaki, N./ Tsiakou, E. K./ Timpanidou, M./ Tsampoulas, C./ Tatsis, C. K./ Kotoulas, K./ Moutsopoulos, H. M.

OBJECTIVE: To evaluate if methotrexate (MTX) can slow disease progression, as determined radiographically, in comparison to other disease modifying drugs in rheumatoid arthritis (RA) patients. MATERIALS AND METHODS: Pairs of hand and wrist radiographs from 30 patients treated with MTX and 30 treated with D-penicillamine (DP) were evaluated blindly and separately by two radiologists (A and B) using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The radiographs studied were obtained at the beginning and 5 years after therapy in both groups. RESULTS: A significantly greater worsening was found in the DP-treated patients (p = 0.025), as compared to MTX patients. Methotrexate showed a slower rate of disease progression than DP. Furthermore, in the MTX group 15 patients remained radiographically stable, 9 worsened and 6 were healed. In contrast, in the DP group 22 patients remained radiographically stable, 8 worsened and none improved. CONCLUSIONS: The rate of radiographic progression in RA patients was lower in MTX-treated patients compared to those treated with DP. Six patients showed radiological improvement after MTX treatment. Therefore, it seems that MTX could be considered a disease modifying drug.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Antirheumatic Agents/*therapeutic use,Arthritis, Rheumatoid/*drug therapy/*radiography,Disease Progression,Female,Hand/radiography,Humans,Longitudinal Studies,Male,Methotrexate/*therapeutic use,Middle Aged,Penicillamine/therapeutic use,Prospective Studies,Wrist/radiography
ISSN: 0392-856X
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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