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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Drosos, A. A. | en |
| dc.contributor.author | Tsifetaki, N. | en |
| dc.contributor.author | Tsiakou, E. K. | en |
| dc.contributor.author | Timpanidou, M. | en |
| dc.contributor.author | Tsampoulas, C. | en |
| dc.contributor.author | Tatsis, C. K. | en |
| dc.contributor.author | Kotoulas, K. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:10:01Z | - |
| dc.date.available | 2015-11-24T19:10:01Z | - |
| dc.identifier.issn | 0392-856X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20778 | - |
| dc.rights | Default Licence | - |
| dc.subject | Aged | en |
| dc.subject | Antirheumatic Agents/*therapeutic use | en |
| dc.subject | Arthritis, Rheumatoid/*drug therapy/*radiography | en |
| dc.subject | Disease Progression | en |
| dc.subject | Female | en |
| dc.subject | Hand/radiography | en |
| dc.subject | Humans | en |
| dc.subject | Longitudinal Studies | en |
| dc.subject | Male | en |
| dc.subject | Methotrexate/*therapeutic use | en |
| dc.subject | Middle Aged | en |
| dc.subject | Penicillamine/therapeutic use | en |
| dc.subject | Prospective Studies | en |
| dc.subject | Wrist/radiography | en |
| dc.title | Influence of methotrexate on radiographic progression in rheumatoid arthritis: a sixty-month prospective study | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9177920 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 1997 | - |
| heal.abstract | OBJECTIVE: To evaluate if methotrexate (MTX) can slow disease progression, as determined radiographically, in comparison to other disease modifying drugs in rheumatoid arthritis (RA) patients. MATERIALS AND METHODS: Pairs of hand and wrist radiographs from 30 patients treated with MTX and 30 treated with D-penicillamine (DP) were evaluated blindly and separately by two radiologists (A and B) using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The radiographs studied were obtained at the beginning and 5 years after therapy in both groups. RESULTS: A significantly greater worsening was found in the DP-treated patients (p = 0.025), as compared to MTX patients. Methotrexate showed a slower rate of disease progression than DP. Furthermore, in the MTX group 15 patients remained radiographically stable, 9 worsened and 6 were healed. In contrast, in the DP group 22 patients remained radiographically stable, 8 worsened and none improved. CONCLUSIONS: The rate of radiographic progression in RA patients was lower in MTX-treated patients compared to those treated with DP. Six patients showed radiological improvement after MTX treatment. Therefore, it seems that MTX could be considered a disease modifying drug. | en |
| heal.journalName | Clin Exp Rheumatol | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
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